Guanine nucleotide binding protein (G protein) beta polypeptide 1
Guanine nucleotide binding protein (G protein) gamma 2
Guanine nucleotide binding protein beta 1 subunit
Guanine nucleotide binding protein G(i) subunit alpha 1
Guanine nucleotide binding protein G(I)/G(O) gamma 2 subunit
Guanine nucleotide binding protein G(I)/G(S)/G(O) subunit gamma 2
Guanine nucleotide binding protein G(I)/G(S)/G(T) beta subunit 1
Guanine nucleotide binding protein G(I)/G(S)/G(T) subunit beta 1
Guanine nucleotide binding protein gamma 2
Platelet activating factor receptor
Transducin beta chain 1
Platelet-activating factor (PAF) is a pro-inflammatory lipid mediator possessing a unique 1-O-alkyl-2-acetylsnglycero-3-phosphocholine backbone.
The PAF receptor (PAFR), which belongs to the superfamily of seven transmembrane (7TM), G-protein coupled receptors (GPCRs), transduces pleiotropic functions including cell motility, smooth muscle contraction, and synthesisand release of mediators and cytokines via multiple
heterotrimeric G-proteins. Pharmacological studies have suggested that PAF functions in a variety of settings including allergy, inflammation, neural functions, reproduction, and atherosclerosis.
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction
PAFR: Cell membrane; Multi-pass membrane protein
GNG2 Cell membrane; Lipid-anchor; Cytoplasmic side
has not yet been referenced specifically in any publications.
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