Recombinant Human PAFR +Gia1ß1?2 fusion co-expressed protein (ab90726)

Overview

  • Product name
    Recombinant Human PAFR +Gia1ß1?2 fusion co-expressed protein
  • Protein length
    Full length protein
  • Description
    Recombinant Human PAFR +Giα1β1γ2 fusion co-expressed protein

Description

  • Nature
    Recombinant
  • Source
    Baculovirus infected Sf9 cells
  • Amino Acid Sequence
    • Species
      Human

Specifications

Our Abpromise guarantee covers the use of ab90726 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 75mM Tris HCl, 12.5mM Magnesium chloride, 1mM EDTA, pH 7.4

General Info

  • Alternative names
    • Adenylate cyclase inhibiting G alpha protein
    • Beta subunit signal transducing proteins GS/GI
    • G gamma I
    • G protein beta 1 subunit
    • Gi
    • Gi1 protein alpha subunit
    • GNAI1
    • GNB1
    • GNG2
    • Guanine nucleotide binding protein (G protein) alpha inhibiting activity polypeptide 1
    • Guanine nucleotide binding protein (G protein) beta polypeptide 1
    • Guanine nucleotide binding protein (G protein) gamma 2
    • Guanine nucleotide binding protein beta 1 subunit
    • Guanine nucleotide binding protein G(i) subunit alpha 1
    • Guanine nucleotide binding protein G(I)/G(O) gamma 2 subunit
    • Guanine nucleotide binding protein G(I)/G(S)/G(O) subunit gamma 2
    • Guanine nucleotide binding protein G(I)/G(S)/G(T) beta subunit 1
    • Guanine nucleotide binding protein G(I)/G(S)/G(T) subunit beta 1
    • Guanine nucleotide binding protein gamma 2
    • PAF R
    • PAFR
    • Platelet activating factor receptor
    • PTAFR
    • Transducin beta chain 1
    see all
  • Relevance
    Platelet-activating factor (PAF) is a pro-inflammatory lipid mediator possessing a unique 1-O-alkyl-2-acetylsnglycero-3-phosphocholine backbone. The PAF receptor (PAFR), which belongs to the superfamily of seven transmembrane (7TM), G-protein coupled receptors (GPCRs), transduces pleiotropic functions including cell motility, smooth muscle contraction, and synthesisand release of mediators and cytokines via multiple heterotrimeric G-proteins. Pharmacological studies have suggested that PAF functions in a variety of settings including allergy, inflammation, neural functions, reproduction, and atherosclerosis. Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction
  • Cellular localization
    PAFR: Cell membrane; Multi-pass membrane protein GNG2 Cell membrane; Lipid-anchor; Cytoplasmic side

References

ab90726 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab90726.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

Sign up