The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
% SDS-PAGE. Human PAI1 stable mutant is reacted with an excess of Human sc-PLAT at physiological pH. The resulting 1:1 molar complex is purified from the remaining PLAT by cobalt metal affinity chromatography resin.
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Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
PAI1 acts as "bait" for tissue plasminogen activator (TPA), urokinase, and protein C. Its rapid interaction with TPA may function as a major control point in the regulation of fibrinolysis.
TPA: This converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events.
Secreted protein; extracellular space.
SDS-PAGE - PAI1 + PLAT protein (Human) (ab92549)
Lane 1: ab92549 (3µg) Reduced
Lane 2: ab92549 (3µg) Non-Reduced
has not yet been referenced specifically in any publications.
Publishing research using ab92549? Please let us know so that we can cite the reference in this datasheet.
Customer reviews and Q&As
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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