Recombinant Human PAI1 + PLAT protein (ab92549)

Overview

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Species
      Human

Specifications

Our Abpromise guarantee covers the use of ab92549 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Purity
    > 95 % SDS-PAGE.
    Human PAI1 stable mutant is reacted with an excess of Human sc-PLAT at physiological pH. The resulting 1:1 molar complex is purified from the remaining PLAT by cobalt metal affinity chromatography resin.
  • Form
    Liquid
  • Additional notes
    Spectrophotometric data: e0.1%=1.56
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 0.4M HEPES, 0.1M Sodium chloride, pH 7.4

General Info

  • Alternative names
    • Alteplase
    • PAI 1
    • PLANH1
    • Plasminogen activator inhibitor 1
    • PLAT
    • Reteplase
    • t PA
    • t plasminogen activator
    • tPA
    see all
  • Relevance
    PAI1 acts as "bait" for tissue plasminogen activator (TPA), urokinase, and protein C. Its rapid interaction with TPA may function as a major control point in the regulation of fibrinolysis. TPA: This converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events.
  • Cellular localization
    Secreted protein; extracellular space.

Images

  • 10% SDS-PAGE
    Lane 1: ab92549 (3µg) Reduced
    Lane 2: ab92549 (3µg) Non-Reduced

References

ab92549 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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