• NatureRecombinant
  • SourceBaculovirus infected Sf9 cells
  • Amino Acid Sequence
    • AccessionQ13177
    • SpeciesHuman
    • Molecular weight87 kDa including tags
    • Amino acids1 to 524


Our Abpromise guarantee covers the use of ab125597 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications


  • Purity> 70 % SDS-PAGE.
    Assessed by densitometry.
  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 7.50
    Constituents: 0.31% Glutathione, 0.002% PMSF, 0.004% DTT, 0.79% Tris HCl, 0.003% EDTA, 25% Glycerol, 0.29% Sodium chloride

General Info

  • Alternative names
    • C-t-PAK2
    • CB422
    • EC
    • Gamma PAK
    • Gamma-PAK
    • hPAK65
    • Kinase
    • p21 (CDKN1A) activated kinase 2
    • p21 (CDKN1A)-activated kinase 2a
    • p21 activated kinase 2
    • p21 protein (Cdc42/Rac)-activated kinase 2
    • p21 protein Cdc42 Rac activated kinase 2
    • p21-activated kinase 2
    • p21-activated kinase, 65-KD
    • p21-activated protein kinase I
    • p21CDKN1A activated kinase 2
    • p27
    • p34
    • p58
    • p65PAK
    • PAK 2
    • PAK-2
    • PAK-2p34
    • Pak2
    • PAK2_HUMAN
    • PAK65
    • PAKgamma
    • S6 H4 kinase
    • S6/H4 kinase
    • Serine threonine protein kinase PAK 2
    • Serine/threonine protein kinase PAK 2
    see all
  • FunctionThe activated kinase acts on a variety of targets. Phosphorylates ribosomal protein S6, histone H4 and myelin basic protein. Full length PAK 2 stimulates cell survival and cell growth. The process is, at least in part, mediated by phosphorylation and inhibition of pro-apoptotic BAD. Caspase-activated PAK-2p34 is involved in cell death response, probably involving the JNK signaling pathway. Cleaved PAK-2p34 seems to have a higher activity than the CDC42-activated form.
  • Tissue specificityUbiquitously expressed. Higher levels seen in skeletal muscle, ovary, thymus and spleen.
  • Sequence similaritiesBelongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
    Contains 1 CRIB domain.
    Contains 1 protein kinase domain.
  • Post-translational
    Full length PAK 2 is autophosphorylated when activated by CDC42/p21. Following cleavage, both peptides, PAK-2p27 and PAK-2p34, become highly autophosphorylated, with PAK-2p27 being phosphorylated on serine and PAK-2p34 on threonine residues, respectively. Autophosphorylation of PAK-2p27 can occur in the absence of any effectors and is dependent on phosphorylation of Thr-402, because PAK-2p27 is acting as an exogenous substrate.
    During apoptosis proteolytically cleaved by caspase-3 or caspase-3-like proteases to yield active PAK-2p34.
    Ubiquitinated, leading to its proteasomal degradation.
    PAK-2p34 is myristoylated.
  • Cellular localizationCytoplasm and Nucleus. Cytoplasm > perinuclear region. Membrane. Interaction with ARHGAP10 probably changes PAK-2p34 location to cytoplasmic perinuclear region. Myristoylation changes PAK-2p34 location to the membrane.
  • Information by UniProt

Recombinant Human PAK2 protein images

References for Recombinant Human PAK2 protein (ab125597)

ab125597 has not yet been referenced specifically in any publications.

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