Overview

Description

  • Nature
    Recombinant
  • Source
    Wheat germ
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      MSDGLDNEEKPPAPPLRMNSNNRDSSALNHSSKPLPMAPEEKNKKARLRS IFPGGGDKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGE
    • Amino acids
      1 to 90
    • Tags
      proprietary tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab159049 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    ELISA

  • Form
    Liquid
  • Additional notes
    Protein concentration is above or equal to 0.05 mg/ml.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • Beta PAK
    • bPAK
    • CDKN1A
    • hPAK3
    • Mental retardation X linked 30
    • MRX30
    • MRX47
    • Oligophrenin 3
    • OPHN3
    • p21 (CDKN1A) activated kinase 3
    • p21 activated kinase 3
    • p21 CDKN1A activated kinase 3
    • P21 protein (Cdc42/Rac) activated kinase 3
    • PAK-3
    • PAK3 p21 protein (Cdc42/Rac)-activated kinase 3
    • PAK3beta
    • Pak65alpha
    • Pak65beta
    • Serine threonine protein kinase PAK 3
    • Stk4
    see all
  • Relevance
    PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins serve as targets for the small GTP binding proteins Cdc42 and RAC and have been implicated in a wide range of biological activities. PAK3 forms an activated complex with GTP-bound RAS-like (P21), CDC2 and RAC1 proteins which then catalyzes a variety of targets. It may be necessary for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity. A point mutation in this gene has been linked to nonsyndromic X-linked mental retardation.
  • Cellular localization
    Cytoplasmic

Images

  • ab159049 on a 12.5% SDS-PAGE stained with Coomassie Blue.

References

ab159049 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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