Recombinant Human PAPP A protein (ab109664)

Overview

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • AccessionQ13219
    • SpeciesHuman
    • SequenceREARGATEEP SPPSRALYFS GRGEQLRLRA DLELPRDAFT LQVWLRAEGG QRSPAVITGL YDKCSYISRD RGWVVGIHTI SDQDNKDPRY FFSLKTDRAR QVTTINAHRS YLPGQWVYLA ATYDGQFMKL YVNGAQVATS GEQVGGIFSP LTQKCKVLML GGSALNHNYR GYIEHFSLWK VARTQREILS DHHHHHH
    • Amino acids81 to 271
    • TagsHis tag C-Terminus

Specifications

Our Abpromise guarantee covers the use of ab109664 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Purity> 95 % SDS-PAGE.

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 6.8
    Constituent: Laemmli buffer

General Info

  • Alternative names
    • ASBABP2
    • Aspecific BCL2 ARE binding protein 2
    • Differentially placenta 1 expressed protein
    • DIPLA1
    • EC 3.4.24.79
    • IGF dependent IGFBP 4 protease
    • IGF-dependent IGFBP-4 protease
    • IGFBP 4ase
    • IGFBP-4ase
    • IGFBP4ase
    • Insulin like growth factor dependent IGF binding protein 4 protease
    • Insulin-like growth factor-dependent IGF-binding protein 4 protease
    • PAPA
    • PAPP A
    • PAPP-A
    • PAPP1_HUMAN
    • PAPPA
    • PAPPA1
    • Pappalysin 1 precursor
    • Pappalysin-1
    • Pregnancy Associated Plasma Protein A
    • Pregnancy associated plasma protein A pappalysin 1
    • Pregnancy-associated plasma protein A
    see all
  • FunctionMetalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF.
  • Tissue specificityHigh levels in placenta and pregnancy serum. In placenta, expressed in X cells in septa and anchoring villi, and in syncytiotrophoblasts in the chorionic villi. Lower levels are found in a variety of other tissues including kidney, myometrium, endometrium, ovaries, breast, prostate, bone marrow, colon, fibroblasts and osteoblasts.
  • Sequence similaritiesBelongs to the peptidase M43B family.
    Contains 5 Sushi (CCP/SCR) domains.
  • Developmental stagePresent in serum and placenta during pregnancy; levels increase throughout pregnancy.
  • Post-translational
    modifications
    There appear to be no free sulfhydryl groups.
  • Cellular localizationSecreted.
  • Information by UniProt

References for Recombinant Human PAPP A protein (ab109664)

ab109664 has not yet been referenced specifically in any publications.

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