The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 6.8 Constituent: Laemmli buffer
Aspecific BCL2 ARE binding protein 2
Differentially placenta 1 expressed protein
IGF dependent IGFBP 4 protease
IGF-dependent IGFBP-4 protease
Insulin like growth factor dependent IGF binding protein 4 protease
Insulin-like growth factor-dependent IGF-binding protein 4 protease
Pappalysin 1 precursor
Pregnancy Associated Plasma Protein A
Pregnancy associated plasma protein A pappalysin 1
Pregnancy-associated plasma protein A
FunctionMetalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF.
Tissue specificityHigh levels in placenta and pregnancy serum. In placenta, expressed in X cells in septa and anchoring villi, and in syncytiotrophoblasts in the chorionic villi. Lower levels are found in a variety of other tissues including kidney, myometrium, endometrium, ovaries, breast, prostate, bone marrow, colon, fibroblasts and osteoblasts.
Sequence similaritiesBelongs to the peptidase M43B family. Contains 5 Sushi (CCP/SCR) domains.
Developmental stagePresent in serum and placenta during pregnancy; levels increase throughout pregnancy.
Post-translational modificationsThere appear to be no free sulfhydryl groups.