Overview

Description

  • Nature
    Recombinant
  • Source
    Wheat germ
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Sequence
      GGLDSATSISASCSQRADSIKPGDSLPTSQAYCPPTYSTTGYSVDPVAGY QYGQYGQSECLVPWASPVPIPSPTPRASCLFMESYKVVSGWGMSISQMEK LKSSQMEQFT
    • Molecular weight
      38 kDa including tags
    • Amino acids
      411 to 521

Specifications

Our Abpromise guarantee covers the use of ab114237 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    ELISA

    SDS-PAGE

    Western blot

  • Form
    Liquid
  • Additional notes
    Protein concentration is above or equal to 0.05 mg/ml
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • FLJ37460
    • HUP1
    • OTTHUMP00000002534
    • Paired box 7
    • Paired box gene 7
    • Paired box homeotic gene 7
    • Paired box protein Pax-7
    • Paired domain gene 7
    • Paired domain gene HuP1
    • Pax7
    • PAX7 transcriptional factor
    • PAX7/FKHR fusion gene, included
    • PAX7_HUMAN
    • PAX7B
    • RGD1564360
    • RMS2
    see all
  • Function
    Probable transcription factor. May have a role in myogenesis.
  • Involvement in disease
    Defects in PAX7 are a cause of rhabdomyosarcoma type 2 (RMS2) [MIM:268220]. It is a form of rhabdomyosarcoma, a highly malignant tumor of striated muscle derived from primitive mesenchimal cells and exhibiting differentiation along rhabdomyoblastic lines. Rhabdomyosarcoma is one of the most frequently occurring soft tissue sarcomas and the most common in children. It occurs in four forms: alveolar, pleomorphic, embryonal and botryoidal rhabdomyosarcomas. Note=A chromosomal aberration involving PAX7 is found in rhabdomyosarcoma. Translocation t(1;13)(p36;q14) with FOXO1. The resulting protein is a transcriptional activator.
  • Sequence similarities
    Belongs to the paired homeobox family.
    Contains 1 homeobox DNA-binding domain.
    Contains 1 paired domain.
  • Cellular localization
    Nucleus.
  • Information by UniProt

Recombinant Human PAX7 protein images

  • 12.5% SDS-PAGE showing ab114237 at approximately 38.21kDa stained with Coomassie Blue.

References for Recombinant Human PAX7 protein (ab114237)

ab114237 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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