Overview

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Sequence
      MGSSHHHHHH SSGLVPRGSH MGSHMEGISN FKTPSKLSEK KKSVLCSTPT INIPASPFMQ KLGFGTGVNV YLMKRSPRGL SHSPWAVKKI NPICNDHYRS VYQKRLMDEA KILKSLHHPN IVGYRAFTEA NDGSLCLAME YGGEKSLNDL IEERYKASQD PFPAAIILKV ALNMARGLKY LHQEKKLLHG DIKSSNVVIK GDFETIKICD VGVSLPLDEN MTVTDPEACY IGTEPWKPKE AVEENGVITD KADIFAFGLT LWEMMTLSIP HINLSNDDDD EDKTFDESDF DDEAYYAALG TRPPINMEEL DESYQKVIEL FSVCTNEDPK DRPSAAHIVE ALETDV
    • Molecular weight
      39 kDa including tags
    • Amino acids
      1 to 322
    • Tags
      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab123196 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Mass Spectrometry

  • Mass spectrometry
    MALDI-TOF
  • Purity
    > 95 % SDS-PAGE.
    ab123196 is purified using conventional chromatography techniques.
  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    pH: 7.20
    Constituents: 0.02% DTT, 0.32% Tris HCl, 10% Glycerol, 0.58% Sodium chloride

General Info

  • Alternative names
    • Cancer/testis antigen 84
    • CT84
    • Epididymis luminal protein 164
    • FLJ14385
    • HEL164
    • Lymphokine activated killer T cell originated protein kinase
    • Lymphokine-activated killer T-cell-originated protein kinase
    • MAPKK like protein kinase
    • MAPKK-like protein kinase
    • Nori 3
    • Nori-3
    • Nori3
    • PBK
    • PDZ binding kinase
    • PDZ-binding kinase
    • Serine/threonine protein kinase
    • Spermatogenesis related protein kinase
    • Spermatogenesis-related protein kinase
    • SPK
    • T LAK cell originated protein kinase
    • T-LAK cell-originated protein kinase
    • TOPK
    • TOPK_HUMAN
    see all
  • Function
    Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage.
  • Tissue specificity
    Expressed in the testis and placenta. In the testis, restrictedly expressed in outer cell layer of seminiferous tubules.
  • Sequence similarities
    Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase kinase subfamily.
    Contains 1 protein kinase domain.
  • Post-translational
    modifications
    Phosphorylated; in a cell-cycle dependent manner at mitosis.
  • Information by UniProt

Images

  • 15% SDS-PAGE showing ab123196 (3µg).
    (Molecular size on SDS-PAGE will appear higher).

References

ab123196 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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