Overview

  • Product nameRecombinant Human PCBD1 protein
  • Protein lengthFull length protein

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • AccessionP61457
    • SpeciesHuman
    • SequenceMGSSHHHHHH SSGLVPRGSH MAGKAHRLSA EERDQLLPNL RAVGWNELEG RDAIFKQFHF KDFNRAFGFM TRVALQAEKL DHHPEWFNVY NKVHITLSTH ECAGLSERDI NLASFIEQVA VSMT
    • Molecular weight14 kDa including tags
    • Amino acids1 to 104
    • TagsHis tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab100942 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Mass Spectrometry

    SDS-PAGE

  • Mass spectrometry
    MALDI-TOF
  • Purity> 95 % SDS-PAGE.
    ab100942 was purified using conventional chromatography techniques.
  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 10% Glycerol, 20mM Tris HCl, 1mM DTT, pH 8

General Info

  • Alternative names
    • 4 alpha hydroxy tetrahydropterin dehydratase
    • 4-alpha-hydroxy-tetrahydropterin dehydratase
    • 6 pyruvoyl tetrahydropterin synthase/dimerization cofactor of hepatocyte nuclear factor 1 alpha
    • 6 pyruvoyl tetrahydropterin synthase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1)
    • DCoH
    • Dimerization cofactor of hepatic nuclear factor 1 alpha
    • Dimerization cofactor of hepatocyte nuclear factor 1 alpha
    • Dimerization cofactor of hepatocyte nuclear factor 1-alpha
    • Dimerization cofactor of HNF1
    • Dimerizing cofactor for HNF1
    • PCBD
    • PCBD 1
    • PCBD1
    • PCD
    • Phenylalanine hydroxylase stimulating protein
    • Phenylalanine hydroxylase-stimulating protein
    • PHS
    • PHS_HUMAN
    • Pterin 4 alpha carbinolamine dehydratase
    • Pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha
    • Pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1)
    • Pterin carbinolamine dehydratase
    • Pterin-4-alpha-carbinolamine dehydratase
    see all
  • FunctionInvolved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2. Coactivator for HNF1A-dependent transcription. Regulates the dimerization of homeodomain protein HNF1A and enhances its transcriptional activity.
  • Involvement in diseaseDefects in PCBD1 are the cause of BH4-deficient hyperphenylalaninemia type D (HPABH4D) [MIM:264070]; also known as hyperphenylalaninemia with primapterinuria. HPABH4D is characterized by the excretion of 7-substituted pterins in the urine of affected patients.
  • Sequence similaritiesBelongs to the pterin-4-alpha-carbinolamine dehydratase family.
  • Cellular localizationCytoplasm. Nucleus. Cytoplasmic and/or nuclear.
  • Information by UniProt

Recombinant Human PCBD1 protein images

  • ab100942, at 3 µg, on 15% SDS PAGE.

References for Recombinant Human PCBD1 protein (ab100942)

ab100942 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab100942.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"