Overview

Description

  • Nature
    Recombinant
  • Source
    Wheat germ
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Molecular weight
      78 kDa including tags
    • Amino acids
      1 to 470

Specifications

Our Abpromise guarantee covers the use of ab112409 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activity
    This product is useful for Antibody Production and Protein Array
  • Applications

    Western blot

    ELISA

    Peptide Array

  • Form
    Liquid
  • Additional notes
    Best used within three months from the date of receipt This product is useful for Antibody Production and Protein Array
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.79% Tris HCl, 0.31% Glutathione
    Note: Glutathione is reduced.

General Info

  • Alternative names
    • Death up-regulated gene protein
    • Dug
    • H731
    • Ma3
    • MGC33046
    • MGC33047
    • Neoplastic transformation inhibitor
    • Neoplastic transformation inhibitor protein
    • Nuclear antigen H731
    • Nuclear antigen H731 like
    • Nuclear antigen H731 like protein
    • Nuclear antigen H731-like
    • PDCD 4
    • Pdcd4
    • PDCD4_HUMAN
    • Programmed cell death 4
    • programmed cell death 4 (neoplastic transformation inhibitor)
    • Programmed cell death protein 4
    • Protein 197/15a
    • Protein MA-3
    • Tis
    • Topoisomerase-inhibitor suppressed protein
    see all
  • Function
    Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA.
  • Tissue specificity
    Up-regulated in proliferative cells. Highly expressed in epithelial cells of the mammary gland. Reduced expression in lung cancer and colon carcinoma.
  • Sequence similarities
    Belongs to the PDCD4 family.
    Contains 2 MI domains.
  • Domain
    Binds EIF4A1 via both MI domains.
  • Post-translational
    modifications
    Polyubiquitinated, leading to its proteasomal degradation. Rapidly degraded in response to mitogens. Phosphorylation of the phosphodegron promotes interaction with BTRC and proteasomal degradation.
  • Cellular localization
    Nucleus. Cytoplasm. Shuttles between the nucleus and cytoplasm. Predominantly nuclear under normal growth conditions, and when phosphorylated at Ser-457. Exported from the nucleus in the absence of serum.
  • Information by UniProt

Recombinant Human PDCD4 protein images

  • 12.5% SDS-PAGE image, using ab112409. (Stained with Coomassie Blue)

References for Recombinant Human PDCD4 protein (ab112409)

ab112409 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab112409.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

Sign up