Overview

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Sequence
      MDVENEQILNVNPADPDNLSDSLFSGDEENAGTEEIKNEINGNWISAYSI NEARINAKAKRRLRKNSSRDSGRGDSVSDSGSDALRSGLTVPTSPKGRLL DRRSRSGKGRGLPKKGGAGGKGVWGTPGQVYDVEEVDVKDPNYDDDQENC VYETVVLPLDERAFEKTLTPIIQEYFEHGDTNEVAEMLRDLNLGEMKSGV PVLAVSLALEGKASHREMTSKLLSDLCGTVMSTTDVEKSFDKLLKDLPEL ALDTPRAPQLVGQFIARAVGDGILCNTYIDSYKGTVDCVQARAALDKATV LLSMSKGGKRKDSVWGSGGGQQSVNHLVKEIDMLLKEYLLSGDISEAEHC LKELEVPHFHHELVYEAIIMVLESTGESTFKMILDLLKSLWKSSTITVDQ MKRGYERIYNEIPDINLDVPHSYSVLERFVEECFQAGIISKQLRDLCPSR GRKRFVSEGDGGRLKPESY
    • Molecular weight
      51 kDa
    • Amino acids
      1 to 469

Specifications

Our Abpromise guarantee covers the use of ab117475 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    HPLC

  • Purity
    > 90 % SDS-PAGE.
    Purity is greater than 90% as determined by RP-HPLC and SDS-PAGE.
  • Form
    Liquid
  • Additional notes
    Although stable 4°C for 4 weeks, should be stored desiccated below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Please see notes section.

    pH: 8.00
    Constituents: 0.32% Tris HCl, 0.02% DTT, 0.58% Sodium chloride

General Info

  • Alternative names
    • Death up-regulated gene protein
    • Dug
    • H731
    • Ma3
    • MGC33046
    • MGC33047
    • Neoplastic transformation inhibitor
    • Neoplastic transformation inhibitor protein
    • Nuclear antigen H731
    • Nuclear antigen H731 like
    • Nuclear antigen H731 like protein
    • Nuclear antigen H731-like
    • PDCD 4
    • Pdcd4
    • PDCD4_HUMAN
    • Programmed cell death 4
    • programmed cell death 4 (neoplastic transformation inhibitor)
    • Programmed cell death protein 4
    • Protein 197/15a
    • Protein MA-3
    • Tis
    • Topoisomerase-inhibitor suppressed protein
    see all
  • Function
    Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA.
  • Tissue specificity
    Up-regulated in proliferative cells. Highly expressed in epithelial cells of the mammary gland. Reduced expression in lung cancer and colon carcinoma.
  • Sequence similarities
    Belongs to the PDCD4 family.
    Contains 2 MI domains.
  • Domain
    Binds EIF4A1 via both MI domains.
  • Post-translational
    modifications
    Polyubiquitinated, leading to its proteasomal degradation. Rapidly degraded in response to mitogens. Phosphorylation of the phosphodegron promotes interaction with BTRC and proteasomal degradation.
  • Cellular localization
    Nucleus. Cytoplasm. Shuttles between the nucleus and cytoplasm. Predominantly nuclear under normal growth conditions, and when phosphorylated at Ser-457. Exported from the nucleus in the absence of serum.
  • Information by UniProt

References

ab117475 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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