Recombinant human PDE4B protein (ab56612)

Overview

Description

  • NatureRecombinant
  • SourceBaculovirus infected Sf9 cells
  • Amino Acid Sequence
    • SpeciesHuman
    • TagsGST tag N-Terminus

Associated products

Specifications

Our Abpromise guarantee covers the use of ab56612 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activitySpecific Activity: 10000 U/µg.
  • Applications

    SDS-PAGE

    Functional Studies

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on Dry Ice. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.

    Preservative: None
    Constituents: 50% Glycerol, 0.05% Tween 20, 5mM Glutathione, 3mM DTT, 25mM Tris HCl, 100mM Sodium chloride, pH 8

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names
    • 5''-cyclic phosphodiesterase 4B
    • cAMP-specific 3''
    • cAMP-specific 3',5'-cyclic phosphodiesterase 4B
    • cAMP-specific phosphodiesterase-4 B isoform
    • DKFZp686F2182
    • DPDE4
    • dunce-like phosphodiesterase E4
    • MGC126529
    • OTTHUMP00000010652
    • OTTHUMP00000010653
    • OTTHUMP00000010654
    • OTTHUMP00000010656
    • OTTHUMP00000232365
    • PDE 4B
    • PDE IVB
    • PDE32
    • Pde4b
    • PDE4B_HUMAN
    • PDE4B5
    • PDEIVB
    • Phosphodiesterase 4B
    • Phosphodiesterase 4B cAMP specific
    • Phosphodiesterase 4B, cAMP specific (phosphodiesterase E4 dunce homolog, Drosophila)
    see all
  • FunctionHydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.
  • Tissue specificityExpressed in brain, heart, lung and skeletal muscle.
  • PathwayPurine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1.
  • Sequence similaritiesBelongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
  • Information by UniProt

References for Recombinant human PDE4B protein (ab56612)

ab56612 has not yet been referenced specifically in any publications.

Product Wall

Merci de nous avoir contactés.

La protéinehttp://www.abcam.com/ab56612est l'isoformePDE4B1 (83.3 kDa) taguée à son extrémitéN-terminale. Le poids moléculaire total est de 109 kDa.

J'e...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"