This product is an active protein and may elicit a biological response in vivo, handle with caution.
cAMP specific 3',5' cyclic phosphodiesterase 4D
5''-cyclic phosphodiesterase 4D
cAMP specific phosphodiesterase 4D
cAMP specific phosphodiesterase PDE4D6
Dunce like phosphodiesterase E3
Phosphodiesterase 4D cAMP specific
Phosphodiesterase 4D cAMP specific (dunce (Drosophila) homolog phosphodiesterase E3)
Phosphodiesterase 4D cAMP specific (phosphodiesterase E3 dunce homolog Drosophila)
Phosphodiesterase 4D, cAMP specific (dunce)
FunctionHydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.
Tissue specificityWidespread; most abundant in skeletal muscle. Isoform 6 is detected in brain. Isoform 8 is detected in brain, placenta, lung and kidney. Isoform 7 is detected in heart and skeletal muscle.
Involvement in diseaseNote=Genetic variations in PDE4D might be associated with susceptibility to stroke. PubMed:17006457 states that association with stroke has to be considered with caution.
Sequence similaritiesBelongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
Post-translational modificationsIsoform 3 and isoform 7 are activated by phosphorylation (in vitro), but not isoform 6. Isoform N3 and isoform 12 are phosphorylated on Ser-49, Ser-51, Ser-55 and Ser-59.
Cellular localizationCytoplasm. Membrane. Cytoplasm > cytoskeleton. Cytoplasm > cytoskeleton > centrosome. Found in the soluble fraction, associated with membranes, and associated with the cytoskeleton and the centrosome.