This product is an active protein and may elicit a biological response in vivo, handle with caution.
Phosphodiesterase 4D cAMP-specific
RelevanceCyclic AMP-dependent phosphodiesterase type D (PDE4D) family is comprised of 5 variants (PDE4D1, D2, D3, D4 and D5). One or more PDE4D subtype-variants are ubiquitously present in all mammalian cells. In CNS all five PDE4D subtype-variants are expressed in varying ratios and their activity is regulated in tandem with GPCRs stimulation. Peripheral tissues also exhibit differential expression of PDE4D variants. PDE4D1/D2 mRNA levels rise in response to an increase in cAMP. Short-term regulation of PDE4D variants involved PKA, MAP kinases and Erk2 phosphorylation that results in rapid change in their enzymatic activities. Other regulatory mechanism involved protein-protein interactions with cytoskeletal scaffolding proteins.
Cellular localizationCell Membrane and Cytoplasmic
Recombinant human PDE4D3 protein images
SDS-PAGE - PDE4D3 protein (Active) (ab80332)
10% SDS-PAGE, Coomassie staining. Lane 1: ab80332, 4µg.Lane 2: Protein marker.
Functional Studies - PDE4D3 protein (Active) (ab80332)