Recombinant human PDE6 alpha protein (ab101586)

Overview

Description

  • NatureRecombinant
  • SourceBaculovirus
  • Amino Acid Sequence
    • AccessionP16499
    • SpeciesHuman
    • Molecular weight120 kDa including tags
    • Amino acids31 to 857

Specifications

Our Abpromise guarantee covers the use of ab101586 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activitythe specific activity of PDE6 alpha was determined to be 38 nmol/min/mg
  • Applications

    Functional Studies

    SDS-PAGE

  • Purity> 70 % SDS-PAGE.
    The purity was determined to be >70% by densitometry
  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF, pH 7.5

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names
    • 5''-cyclic phosphodiesterase subunit alpha
    • CGPR A
    • GMP PDE alpha
    • GMP-PDE alpha
    • PDE 6 alpha
    • PDE 6A
    • PDE V B1
    • PDE V-B1
    • PDE6A
    • PDE6A_HUMAN
    • PDEA
    • Phosphodiesterase 6 alpha
    • Phosphodiesterase 6A alpha subunit
    • Phosphodiesterase 6A cGMP specific rod alpha
    • Retinal Rod Photoreceptor cGMP Phosphodiesterase alpha
    • Rod cGMP specific 3' 5' cyclic phosphodiesterase alpha subunit
    • Rod cGMP-specific 3''
    see all
  • FunctionThis protein participates in processes of transmission and amplification of the visual signal.
  • Involvement in diseaseDefects in PDE6A are the cause of retinitis pigmentosa type 43 (RP43) [MIM:613810]. RP43 is a retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
  • Sequence similaritiesBelongs to the cyclic nucleotide phosphodiesterase family.
    Contains 2 GAF domains.
  • Cellular localizationCell membrane.
  • Information by UniProt

Recombinant human PDE6 alpha protein images

  • SDS Page analysis of ab101586
  • Specific activity of ab101586

References for Recombinant human PDE6 alpha protein (ab101586)

ab101586 has not yet been referenced specifically in any publications.

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