Recombinant human PDE6 beta protein (ab125593)

Overview

Description

  • NatureRecombinant
  • SourceBaculovirus infected Sf9 cells
  • Amino Acid Sequence
    • AccessionP35913
    • SpeciesHuman
    • Molecular weight124 kDa including tags
    • Amino acids1 to 854

Specifications

Our Abpromise guarantee covers the use of ab125593 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activityThe specific activity of ab125593 was determined to be 19 nmol/min/mg.
  • Applications

    Functional Studies

    SDS-PAGE

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 7.50
    Constituents: 0.31% Glutathione, 0.002% PMSF, 0.004% DTT, 0.79% Tris HCl, 0.003% EDTA, 25% Glycerol, 0.88% Sodium chloride

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names
    • 5''-cyclic phosphodiesterase subunit beta
    • Congenital stationary night blindness 3 autosomal dominant
    • CSNB 3
    • CSNB3
    • CSNBAD2
    • GMP PDE beta
    • GMP-PDE beta
    • PDE 6 beta
    • PDE 6B
    • PDE6B
    • PDE6B_HUMAN
    • PDEB
    • Phosphodiesterase 6B
    • Phosphodiesterase 6B cGMP specific rod beta
    • Rd 1
    • Rd1
    • Rod cGMP phosphodiesterase beta subunit
    • Rod cGMP specific 3' 5' cyclic phosphodiesterase beta subunit
    • Rod cGMP-specific 3''
    • RP40
    see all
  • FunctionThis protein participates in processes of transmission and amplification of the visual signal. Necessary for the formation of a functional phosphodiesterase holoenzyme.
  • Involvement in diseaseDefects in PDE6B are the cause of retinitis pigmentosa type 40 (RP40) [MIM:613801]. RP40 is a retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
    Defects in PDE6B are a cause of congenital stationary night blindness autosomal dominant type 2 (CSNBAD2) [MIM:163500]; also known as congenital stationary night blindness Rambusch type. Congenital stationary night blindness is a non-progressive retinal disorder characterized by impaired night vision.
  • Sequence similaritiesBelongs to the cyclic nucleotide phosphodiesterase family.
    Contains 2 GAF domains.
  • Cellular localizationMembrane.
  • Information by UniProt

Recombinant human PDE6 beta protein images

  • SDS Page analysis of ab125593
  • The specific activity of ab125593 was determined to be 19 nmol/min/mg.

References for Recombinant human PDE6 beta protein (ab125593)

ab125593 has not yet been referenced specifically in any publications.

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