Recombinant human PDE6 beta protein (ab125593)

Overview

Description

  • Nature
    Recombinant
  • Source
    Baculovirus infected Sf9 cells
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Molecular weight
      124 kDa including tags
    • Amino acids
      1 to 854

Specifications

Our Abpromise guarantee covers the use of ab125593 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activity
    The specific activity of ab125593 was determined to be 19 nmol/min/mg.
  • Applications

    Functional Studies

    SDS-PAGE

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 7.50
    Constituents: 0.31% Glutathione, 0.002% PMSF, 0.004% DTT, 0.79% Tris HCl, 0.003% EDTA, 25% Glycerol, 0.88% Sodium chloride

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names
    • 5''-cyclic phosphodiesterase subunit beta
    • Congenital stationary night blindness 3 autosomal dominant
    • CSNB 3
    • CSNB3
    • CSNBAD2
    • GMP PDE beta
    • GMP-PDE beta
    • PDE 6 beta
    • PDE 6B
    • PDE6B
    • PDE6B_HUMAN
    • PDEB
    • Phosphodiesterase 6B
    • Phosphodiesterase 6B cGMP specific rod beta
    • Rd 1
    • Rd1
    • Rod cGMP phosphodiesterase beta subunit
    • Rod cGMP specific 3' 5' cyclic phosphodiesterase beta subunit
    • Rod cGMP-specific 3''
    • RP40
    see all
  • Function
    This protein participates in processes of transmission and amplification of the visual signal. Necessary for the formation of a functional phosphodiesterase holoenzyme.
  • Involvement in disease
    Defects in PDE6B are the cause of retinitis pigmentosa type 40 (RP40) [MIM:613801]. RP40 is a retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
    Defects in PDE6B are a cause of congenital stationary night blindness autosomal dominant type 2 (CSNBAD2) [MIM:163500]; also known as congenital stationary night blindness Rambusch type. Congenital stationary night blindness is a non-progressive retinal disorder characterized by impaired night vision.
  • Sequence similarities
    Belongs to the cyclic nucleotide phosphodiesterase family.
    Contains 2 GAF domains.
  • Cellular localization
    Membrane.
  • Information by UniProt

Recombinant human PDE6 beta protein images

  • SDS Page analysis of ab125593
  • The specific activity of ab125593 was determined to be 19 nmol/min/mg.

References for Recombinant human PDE6 beta protein (ab125593)

ab125593 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab125593.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

Sign up