Overview

Description

  • NatureRecombinant
  • SourceWheat germ
  • Amino Acid Sequence
    • AccessionP51160
    • SpeciesHuman
    • SequenceEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSE LTQVEESALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFL
    • Molecular weight36 kDa including tags
    • Amino acids3 to 100

Specifications

Our Abpromise guarantee covers the use of ab116895 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Western blot

    ELISA

  • FormLiquid
  • Additional notesProtein concentration is above or equal to 0.05 mg/ml. This protein is best used within three months from the date of receipt.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • 5''-cyclic phosphodiesterase subunit alpha''
    • cGMP phosphodiesterase 6C
    • COD4
    • Cone cGMP specific 3' 5' cyclic phosphodiesterase subunit alpha'
    • Cone cGMP-specific 3''
    • PDE 6C
    • PDE6 alpha prime
    • PDE6 alpha'
    • PDE6C
    • PDE6C_HUMAN
    • PDEA2
    • Phosphodiesterase 6C cGMP specific cone alpha prime
    see all
  • Involvement in diseaseDefects in PDE6C are the cause of cone dystrophy type 4 (COD4) [MIM:613093]. An early-onset cone dystrophy. Cone dystrophies are retinal dystrophies characterized by progressive degeneration of the cone photoreceptors with preservation of rod function, as indicated by electroretinogram. However, some rod involvement may be present in some cone dystrophies, particularly at late stage. Affected individuals suffer from photophobia, loss of visual acuity, color vision and central visual field. Another sign is the absence of macular lesions for many years. Cone dystrophies are distinguished from the cone-rod dystrophies in which some loss of peripheral vision also occurs.
  • Sequence similaritiesBelongs to the cyclic nucleotide phosphodiesterase family.
    Contains 2 GAF domains.
  • Cellular localizationCell membrane.
  • Information by UniProt

Recombinant Human PDE6C protein images

  • 12.5% SDS-PAGE showing ab116895 at approximately 36.41kDa stained with Coomassie Blue.

References for Recombinant Human PDE6C protein (ab116895)

ab116895 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab116895.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"