FunctionHydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes.
Tissue specificityExpressed in all tissues examined (testis, brain, small intestine, skeletal muscle, heart, lung, thymus, spleen, placenta, kidney, liver, pancreas, ovary and prostate) except blood. Highest levels in brain, heart, kidney, spleen, prostate and colon. Isoform PDE9A12 is found in prostate.
Sequence similaritiesBelongs to the cyclic nucleotide phosphodiesterase family. PDE9 subfamily.
DomainComposed of a C-terminal catalytic domain containing two putative divalent metal sites and an N-terminal regulatory domain.