Recombinant Human PDP1 protein (ab110357)

Overview

  • Product name
    Recombinant Human PDP1 protein
  • Protein length
    Full length protein

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Amino acids
      72 to 537

Specifications

Our Abpromise guarantee covers the use of ab110357 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Functional Studies

    Sandwich ELISA

  • Purity
    > 90 % Purified via His tag.

  • Form
    Liquid
  • Additional notes

    The pyruvate dehydrogenase complex (PDH) is at the center of aerobic carbohydrate metabolism. It is localized in the matrix space of mitochondria where it catalyzes the irreversible oxidative decarboxylation of pyruvate entering the organelle to produce acetyl-CoA, NADH and CO2. PDH is a complex of three different enzymes that channel substrate and product. These are pyruvate dehydrogenase (E1), dihydrolipoamide transacetylase (E2) and dihydrolipoamide dehydrogenase (E3). PDH deficiencies, diabetes, starvation, sepsis, and possibly Alzheimer's disease have been linked to altered PDH functioning.

    Product was previously marketed under the MitoSciences sub-brand.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 7.50
    Constituents: 0.14% Sodium phosphate, 1.46% Sodium chloride, 30% Glycerol, 0.08% DTT, 0.02% EDTA, 0.05% Triton-X-100

General Info

  • Alternative names
    • [Pyruvate dehydrogenase [acetyl transferring]] phosphatase 1, mitochondrial
    • [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1
    • FLJ32517
    • Gm1024
    • MGC119646
    • mitochondrial
    • PDH
    • PDP
    • PDP 1
    • Pdp1
    • PDP1_HUMAN
    • PDPC
    • PDPC 1
    • PPM2C
    • Protein phosphatase 2C
    • protein phosphatase 2C, magnesium dependent, catalytic subunit
    • Pyruvate dehydrogenase (Lipoamide) phosphatase phosphatase
    • Pyruvate dehydrogenase phosphatase catalytic subunit 1
    • Pyruvate dehydrogenase phosphatase, catalytic subunit 1
    • RP23 203A12.1
    see all
  • Function
    Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex.
  • Involvement in disease
    Defects in PDP1 are the cause of pyruvate dehydrogenase phosphatase deficiency (PDP deficiency) [MIM:608782]. PDP deficiency results in lactic acidosis leading to neurological dysfunction.
  • Sequence similarities
    Belongs to the PP2C family.
  • Cellular localization
    Mitochondrion matrix.
  • Information by UniProt

References for Recombinant Human PDP1 protein (ab110357)

ab110357 has not yet been referenced specifically in any publications.

Product Wall

We advise use of PBS for homogenization of muscle tissue. We have not tested the use of this kit with fat tissue. If you have a favorite homogenization buffer, we would advice to prepare the homogenates of both tissues in both buffers in parallel , run...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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