Overview

  • Product name
    Recombinant Human PDZK1 protein
  • Protein length
    Full length protein

Description

  • Nature
    Recombinant
  • Source
    Wheat germ
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Sequence
      MTSTFNPRECKLSKQEGQNYGFFLRIEKDTEGHLVRVVEKCSPAEKAGLQ DGDRVLRINGVFVDKEEHMQVVDLVRKSGNSVTLLVLDGDSYEKAVKTRV DLKELGQSQKEQGLSDNILSPVMNGGVQTWTQPRLCYLVKEGGSYGFSLK TVQGKKGVYMTDITPQGVAMRAGVLADDHLIEVNGENVEDASHEEVVEKV KKSGSRVMFLLVDKETDKRHVEQKIQFKRETASLKLLPHQPRIVEMKKGS NGYGFYLRAGSEQKGQIIKDIDSGSPAEEAGLKNNDLVVAVNGESVETLD HDSVVEMIRKGGDQTSLLVVDKETDNMYRLAHFSPFLYYQSQELPNGSVK EAPAPTPTSLEVSSPPDTTEEVDHKPKLCRLAKGENGYGFHLNAIRGLPG SFIKEVQKGGPADLAGLEDEDVIIEVNGVNVLDEPYEKVVDRIQSSGKNV TLLVCGKKAYDYFQAKKIPIVSSLADPLDTPPDSKEGIVVESNHDSHMAK ERAHSTASHSSSNSEDTEM
    • Molecular weight
      83 kDa including tags
    • Amino acids
      1 to 519

Specifications

Our Abpromise guarantee covers the use of ab114476 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    ELISA

    SDS-PAGE

    Western blot

  • Form
    Liquid
  • Additional notes
    Protein concentration is above or equal to 0.05 mg/ml.
    Best used within three months from the date of receipt.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • 1700023D20Rik
    • 2610507N21Rik
    • 4921513F16Rik
    • AI267131
    • AI314638
    • AL022680
    • C terminal linking and modulating protein
    • CAP70
    • CFTR associated protein of 70 kDa
    • CFTR associated protein, 70-KD
    • CFTR-associated protein of 70 kDa
    • CLAMP
    • D3Ertd537e
    • Dietary Pi-regulated RNA-1
    • Diphor-1
    • mPDZK1
    • Na(+)/H(+) exchange regulatory cofactor NHE-RF3
    • Na(+)/H(+) exchanger regulatory factor 3
    • Na/Pi cotransporter C-terminal-associated protein
    • Na/Pi cotransporter C-terminal-associated protein 1
    • NaPi Cap1
    • NaPi-Cap1
    • NaPiCap1
    • NHERF 3
    • NHERF-3
    • NHERF3
    • NHRF3_HUMAN
    • OTTHUMP00000015572
    • PDZ domain containing 1
    • PDZ domain containing protein 1
    • PDZ domain-containing protein 1
    • PDZD1
    • PDZK1
    • Sodium hydrogen exchanger regulatory factor 3
    • Sodium-hydrogen exchanger regulatory factor 3
    see all
  • Function
    A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity. May function to connect SCARB1 with the cellular machineries for intracellular cholesterol transport and/or metabolism. May be involved in the regulation of proximal tubular Na(+)-dependent inorganic phosphate cotransport therefore playing an important role in tubule function.
  • Tissue specificity
    Expression is limited to epithelial cells. Expressed in the kidney (brush border of proximal tubule), pancreas, liver, and small intestine. Expressed at a lower level in the adrenal cortex, testis and stomach. Overexpressed in breast, renal and lung carcinomas.
  • Sequence similarities
    Belongs to the NHER family.
    Contains 4 PDZ (DHR) domains.
  • Domain
    The PDZ 2 and 3 domains seem to be involved in the interaction with SLC26A3.
    Interaction with the C-terminus of CFTR could be mediated through independent binding of PDZ 1, 3 and 4 domains.
    The PDZ 1 and 3 domains seem to be involved in the interaction with SLCO1A1.
    The PDZ 1 domain interacts with BCR.
  • Cellular localization
    Cytoplasm. Membrane. Associated with peripheral membranes. Localizes to the apical compartment of proximal tubular cells and to sinusoidal liver membranes.
  • Information by UniProt

Images

  • ab114476 analysed on a 12.5% SDS-PAGE gel stained with Coomassie Blue.

References

ab114476 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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