The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Additional notesFor long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term.
pH: 7.50 Constituents: 0.32% Tris HCl, 0.02% DTT, 10% Glycerol
15 kDa phosphoprotein enriched in astrocytes
Astrocytic phosphoprotein PEA 15
Astrocytic phosphoprotein PEA-15
Astrocytic phosphoprotein PEA15
Homolog of mouse MAT 1 oncogene
Homolog of mouse MAT1 oncogene
Phosphoprotein enriched in astrocytes 15
Phosphoprotein enriched in astrocytes 15kD
Phosphoprotein enriched in diabetes
FunctionBlocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm (By similarity). Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface.
Tissue specificityUbiquitously expressed. Most abundant in tissues such as heart, brain, muscle and adipose tissue which utilize glucose as an energy source. Lower expression in glucose-producing tissues. Higher levels of expression are found in tissues from individuals with type 2 diabetes than in controls.