Overview

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • SpeciesHuman
    • SequenceMAEYGTLLQD LTNNITLEDL EQLKSACKED IPSEKSEEIT TGSAWFSFLE SHNKLDKDNL SYIEHIFEIS RRPDLLTMVV DYRTRVLKIS EEDELDTKLT RIPSAKKYKD IIRQPSEEEI IKLAPPPKKA

Specifications

Our Abpromise guarantee covers the use of ab87717 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Purity> 90 % SDS-PAGE.
    Purified by using conventional chromatography.
  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    Preservative: None
    Constituents: 10% Glycerol, 20mM Tris HCl, 1mM DTT, pH 7.5

General Info

  • Alternative names
    • 15 kDa phosphoprotein enriched in astrocytes
    • Astrocytic phosphoprotein PEA 15
    • Astrocytic phosphoprotein PEA-15
    • Astrocytic phosphoprotein PEA15
    • HMAT 1
    • HMAT1
    • Homolog of mouse MAT 1 oncogene
    • Homolog of mouse MAT1 oncogene
    • HUMMAT 1H
    • HUMMAT1H
    • MAT 1
    • MAT 1H
    • MAT1
    • MAT1H
    • PEA 15
    • Pea15
    • PEA15 protein
    • PEA15_HUMAN
    • PED
    • Phosphoprotein enriched in astrocytes 15
    • Phosphoprotein enriched in astrocytes 15kD
    • Phosphoprotein enriched in diabetes
    see all
  • FunctionBlocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm (By similarity). Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface.
  • Tissue specificityUbiquitously expressed. Most abundant in tissues such as heart, brain, muscle and adipose tissue which utilize glucose as an energy source. Lower expression in glucose-producing tissues. Higher levels of expression are found in tissues from individuals with type 2 diabetes than in controls.
  • Sequence similaritiesContains 1 DED (death effector) domain.
  • Post-translational
    modifications
    Phosphorylated by protein kinase C and calcium-calmodulin-dependent protein kinase. These phosphorylation events are modulated by neurotransmitters or hormones.
  • Cellular localizationCytoplasm. Associated with microtubules.
  • Information by UniProt

Recombinant Human PEA15 protein images

  • ab87717 on 15% SDS-PAGE (3µg)

References for Recombinant Human PEA15 protein (ab87717)

ab87717 has not yet been referenced specifically in any publications.

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