Overview

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Sequence
      MPAVTQHAPY FKGTAVVNGE FKDLSLDDFK GKYLVLFFYP LDFTFVCPTE IVAFSDKANE FHDVNCEVVA VSVDSHFSHL AWINTPRKNG GLGHMNIALL SDLTKQISRD YGVLLEGSGL ALRGLFIIDP NGVIKHLSVN DLPVGRSVEE TLRLVKAFQY VETHGEVCPA NWTPDSPTIK PSPAASKEYF QKVNQ
    • Molecular weight
      22 kDa
    • Amino acids
      63 to 256

Associated products

Specifications

Our Abpromise guarantee covers the use of ab168006 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activity
    Specific activity: approximately 82-83 pmole/min/µg.
    Enzymatic activity was confirmed by measuring the remaining peroxide after incubation of Peroxiredoxin 3 and peroxide for 20 min at room temperature. Specific activity is defined as the amount of hydroperoxide that 1 µg of enzyme can reduce at 25°C for 1 minute.
  • Applications

    SDS-PAGE

    Functional Studies

  • Purity
    >95% by SDS-PAGE .

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.32% Tris HCl, 10% Glycerol

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names
    • Antioxidant protein 1
    • AOP 1
    • AOP-1
    • AOP1
    • HBC189
    • MER5
    • MGC104387
    • MGC24293
    • mitochondrial
    • peroxiredoxin 3
    • Peroxiredoxin III
    • Peroxiredoxin-3
    • PRDX3
    • PRDX3_HUMAN
    • PRO1748
    • Protein MER5 homolog
    • PRX III
    • Prx-III
    • PRX3
    • SP 22
    • SP-22
    • SP22
    • Thioredoxin dependent peroxide reductase mitochondrial
    • Thioredoxin-dependent peroxide reductase
    see all
  • Function
    Involved in redox regulation of the cell. Protects radical-sensitive enzymes from oxidative damage by a radical-generating system. Acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol.
  • Sequence similarities
    Belongs to the ahpC/TSA family.
    Contains 1 thioredoxin domain.
  • Cellular localization
    Mitochondrion.
  • Information by UniProt

Images

  • 15% SDS-PAGE analysis of 3µg ab168006.

References

This product has been referenced in:
  • Lin LH  et al. Serum proteomic-based analysis identifying autoantibodies against PRDX2 and PRDX3 as potential diagnostic biomarkers in nasopharyngeal carcinoma. Clin Proteomics 14:6 (2017). Read more (PubMed: 28184180) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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