The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Endotoxin level< 0.100 Eu/µg
Additional notesThe biological activity of this product is determined by its ability to chemoattract human fibroblasts using a concentration range of 1.0-10.0 ng/ml.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
This product is an active protein and may elicit a biological response in vivo, handle with caution.
ReconstitutionReconstitute in 200ul sterile water to a conc. of 0.1 mg/ml.
C-X-C motif chemokine 4
Chemokine (C X C motif) ligand 4
Chemokine (CXC motif) ligand 4
Platelet factor 4
Small inducible cytokine subfamily member 4
FunctionReleased during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation, the short form is a more potent inhibitor than the longer form.
Sequence similaritiesBelongs to the intercrine alpha (chemokine CxC) family.
Post-translational modificationsBinds non-covalently to a proteoglycan molecule.