Overview

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • SpeciesHuman
    • TagsGST tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab82628 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    SDS-PAGE

  • Purity> 90 % SDS-PAGE.

  • FormLyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.

    Preservative: None
    Constituents: 50mM Tris, 10mM GSH, pH 8

  • ReconstitutionPackaging size : 0.1 mg

General Info

  • Alternative names
    • Epididymis luminal protein 117
    • Epididymis secretory protein Li 53
    • HEL 117
    • HEL S 53
    • NDGOA
    • Neuron cytoplasmic protein 9.5
    • OTTHUMP00000218137
    • OTTHUMP00000218139
    • OTTHUMP00000218140
    • OTTHUMP00000218141
    • Park 5
    • PARK5
    • PGP 9.5
    • PGP9.5
    • PGP95
    • Protein gene product 9.5
    • Ubiquitin C terminal esterase L1
    • Ubiquitin C terminal hydrolase
    • Ubiquitin C terminal hydrolase L1
    • Ubiquitin carboxyl terminal esterase L1
    • Ubiquitin carboxyl terminal hydrolase isozyme L1
    • Ubiquitin carboxyl-terminal hydrolase isozyme L1
    • Ubiquitin thioesterase L1
    • Ubiquitin thiolesterase
    • Ubiquitin thiolesterase L1
    • UCH-L1
    • UCHL1
    • UCHL1_HUMAN
    see all
  • FunctionUbiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity.
  • Tissue specificityFound in neuronal cell bodies and processes throughout the neocortex (at protein level). Expressed in neurons and cells of the diffuse neuroendocrine system and their tumors. Weakly expressed in ovary. Down-regulated in brains from Parkinson disease and Alzheimer disease patients.
  • Involvement in diseaseParkinson disease 5
    Neurodegeneration with optic atrophy, childhood-onset
  • Sequence similaritiesBelongs to the peptidase C12 family.
  • Post-translational
    modifications
    O-glycosylated.
  • Cellular localizationCytoplasm. Endoplasmic reticulum membrane. About 30% of total UCHL1 is associated with membranes in brain.
  • Information by UniProt

Recombinant Human PGP9.5 protein images

  • ab82628 at 1µg on SDS-PAGE.

References for Recombinant Human PGP9.5 protein (ab82628)

ab82628 has not yet been referenced specifically in any publications.

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