Overview

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • AccessionP39687
    • SpeciesHuman
    • SequenceMGSSHHHHHHSSGLVPRGSHMEMGRRIHLELRNRTPSDVKELVLDNSRSN EGKLEGLTDEFEELEFLSTINVGLTSIANLPKLNKLKKLELSDNRVSGGL EVLAEKCPNLTHLNLSGNKIKDLSTIEPLKKLENLKSLDLFNCEVTNLND YRENVFKLLPQLTYLDGYDRDDKEAPDSDAEGYVEGLDDEEEDEDEEEYD EDAQVVEDEEDEDEEEEGEEEDVSGEEEEDEEGYNDGEVDDEEDEEELGE EERGQKRKREPEDEGEDDD
    • Molecular weight31 kDa including tags
    • Amino acids1 to 249
    • TagsHis tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab101155 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Mass Spectrometry

  • Mass spectrometry
    MALDI-TOF
  • Purity> 90 % SDS-PAGE.
    ab101155 was purified using conventional chromatography techniques.
  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    Preservative: 0% None
    Constituents: 10% Glycerol, 20mM Tris HCl, 100mM Sodium chloride, 1mM DTT, 0.1mM PMSF, pH 8.0

General Info

  • Alternative names
    • acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
    • Acidic leucine-rich nuclear phosphoprotein 32 family member A
    • Acidic nuclear phosphoprotein 32 family member A
    • Acidic nuclear phosphoprotein pp32
    • AN32A_HUMAN
    • ANP32A
    • C15orf1
    • Cerebellar leucine rich acidic nuclear protein
    • Hepatopoietin Cn
    • HPPCn
    • I1PP2A
    • Inhibitor 1 of protein phosphatase 2A
    • inhibitor-1 of protein phosphatase-2A
    • Lanp
    • Leucine rich acidic nuclear protein
    • Leucine-rich acidic nuclear protein
    • MAPM
    • Mapmodulin
    • MGC119787
    • MGC150373
    • PHAPI
    • Potent heat stable protein phosphatase 2A inhibitor I1PP2A
    • Potent heat-stable protein phosphatase 2A inhibitor I1PP2A
    • PP32
    • Putative HLA DR associated protein I
    • Putative HLA-DR-associated protein I
    • Putative human HLA class II associated protein I
    • Putative human HLA class II-associated protein
    see all
  • FunctionImplicated in a number of cellular processes, including proliferation, differentiation, caspase-dependent and caspase-independent apoptosis, suppression of transformation (tumor suppressor), inhibition of protein phosphatase 2A, regulation of mRNA trafficking and stability in association with ELAVL1, and inhibition of acetyltransferases as part of the INHAT (inhibitor of histone acetyltransferases) complex. Plays a role in E4F1-mediated transcriptional repression.
  • Tissue specificityExpressed in all tissues tested. Highly expressed in kidney and skeletal muscle, moderate levels of expression in brain, placenta and pancreas, and weakly expressed in lung. Found in all regions of the brain examined (amygdala, caudate nucleus, corpus callosum, hippocampus and thalamus), with highest levels in amygdala.
  • Sequence similaritiesBelongs to the ANP32 family.
    Contains 4 LRR (leucine-rich) repeats.
    Contains 1 LRRCT domain.
  • Post-translational
    modifications
    Phosphorylated on serine residues.
    The N-terminus is blocked.
    Some glutamate residues are glycylated by TTLL8. This modification occurs exclusively on glutamate residues and results in a glycine chain on the gamma-carboxyl group.
  • Cellular localizationNucleus. Cytoplasm. Endoplasmic reticulum. Translocates to the cytoplasm during the process of neuritogenesis (By similarity). Shuttles between nucleus and cytoplasm.
  • Information by UniProt

Recombinant Human PHAP1 protein images

  • 15% SDS-PAGE (3 µg)

References for Recombinant Human PHAP1 protein (ab101155)

ab101155 has not yet been referenced specifically in any publications.

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