Recombinant human PI 3 Kinase catalytic subunit gamma protein (ab125538)

Overview

Description

  • Nature
    Recombinant
  • Source
    Baculovirus infected Sf9 cells
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Molecular weight
      121 kDa including tags
    • Amino acids
      1 to 1102
    • Tags
      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab125538 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activity
    The specific activity of ab125538 was determined to be 52 nmol/min/mg.
  • Applications

    Western blot

    Functional Studies

    SDS-PAGE

  • Purity
    > 85 % Densitometry.
    Purity determined to be >85% by densitometry.
  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 7.00
    Preservative: 1.02% Imidazole
    Constituents: 0.002% PMSF, 0.81% Sodium phosphate, 0.004% DTT, 25% Glycerol, 1.75% Sodium chloride

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names
    • 1 phosphatidylinositol 3 kinase
    • 5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma
    • 5-bisphosphate 3-kinase catalytic subunit gamma isoform
    • p110 gamma
    • p110gamma
    • p120 PI3K
    • p120-PI3K
    • Phosphatidylinositol 3 kinase catalytic 110 kD gamma
    • Phosphatidylinositol 3 kinase gamma, p110 gamma
    • Phosphatidylinositol 3 kinase, catalytic, gamma polypeptide
    • Phosphatidylinositol 4 5 bisphosphate 3 kinase 110 kDa catalytic subunit gamma
    • Phosphatidylinositol 4 5 bisphosphate 3 kinase catalytic subunit gamma
    • Phosphatidylinositol 4 5 bisphosphate 3 kinase catalytic subunit gamma isoform
    • Phosphatidylinositol-4
    • Phosphoinositide 3 kinase catalytic gamma polypeptide
    • Phosphoinositide 3 kinase gamma catalytic subunit
    • PI3 kinase p110 subunit gamma
    • PI3-kinase subunit gamma
    • PI3CG
    • PI3K
    • PI3K-gamma
    • PI3Kgamma
    • PIK3
    • Pik3cg
    • PK3CG_HUMAN
    • PtdIns-3-kinase subunit gamma
    • PtdIns-3-kinase subunit p110-gamma
    • Serine/threonine protein kinase PIK3CG
    see all
  • Function
    3-phosphorylates the cellular phosphoinositide PtdIns-4,5-biphosphate (PtdIns(4,5)P2) to produce PtdIns-3, 4,5-triiphosphate (PtdIns(3,4,5)P3). Links G-protein coupled receptor activation to the secondary messenger PtdIns(3,4,5)P3 production.
  • Tissue specificity
    Pancreas, skeletal muscle, liver and heart.
  • Pathway
    Phospholipid metabolism; phosphatidylinositol phosphate biosynthesis.
  • Sequence similarities
    Belongs to the PI3/PI4-kinase family.
    Contains 1 PI3K/PI4K domain.
  • Information by UniProt

Images

  • SDS-PAGE analysis of ab125538.
  • The specific activity of ab125538 was determined to be 52 nmol/min/mg by Kinase Assay.

References

ab125538 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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