This product is an active protein and may elicit a biological response in vivo, handle with caution.
Phosphatidylinositol 4 kinase type 2 beta
Phosphatidylinositol 4 kinase type II beta
Phosphatidylinositol 4-kinase type 2-beta
Phosphatidylinositol 4-kinase type II-beta
PI4K 2 beta
PI4K II beta
Type II phosphatidylinositol 4 kinase beta isoform
FunctionTogether with PI4K2A and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. This contribution may be especially significant in plasma membrane, endosomal and Golgi compartments. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells and is likely to be involved in the regulation of vesicular trafficking.
Tissue specificityWidely expressed.
Sequence similaritiesBelongs to the PI3/PI4-kinase family. Type II PI4K subfamily. Contains 1 PI3K/PI4K domain.
Cellular localizationCytoplasm. Membrane. Mostly cytoplasmic but also found associated with the plasma membrane, the Golgi and endosomes. Compared to PI4K2A, a larger fraction of PI4K2B is cytosolic due to a smaller extent of palmitoylation. Translocates to membranes where it is recruited by PDGF stimulation by a Rac-GTP-dependent mechanism.