The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Protein concentration is above or equal to 0.05 mg/ml.
Concentration information loading...
Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.31% Glutathione, 0.79% Tris HCl
Cap specific guanine N2 methyltransferase
Cap-specific guanine-N2 methyltransferase
CLL associated antigen KW 2
CLL-associated antigen KW-2
Hepatocellular carcinoma associated antigen 137
Hepatocellular carcinoma-associated antigen 137
Nuclear receptor coactivator 6 interacting protein
Nuclear receptor coactivator 6-interacting protein
PRIP interacting protein PIPMT
PRIP interacting protein with methyltransferase domain
PRIP interacting protein with methyltransferase motif
PRIP-interacting protein with methyltransferase motif
Trimethylguanosine synthase homolog
Trimethylguanosine synthase homolog (S. cerevisiae)
Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation.
Ubiquitously expressed. High expression in heart, skeletal muscle, kidney, liver and placenta.
Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family.
Cytoplasm. Nucleus > Cajal body. A 90 kDa isoform is found in the nucleus while a 55 kDa isoform is found in the cytoplasm and colocalizes with the tubulin network.