Overview

  • Product name
    Recombinant Human PIMT protein
  • Protein length
    Full length protein

Description

  • Nature
    Recombinant
  • Source
    Wheat germ
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      MRVIAIDIDPVKIALARNNAEVYGIADKIEFICGDFLLLASFLKADVVFL SPPWGGPDYATAETFDIRTMMSPDGFEIFRLSKKITNNIVYFLPRNADID QVASLAGPGGQVEIEQNFLNNKLKTITAYFGDLIRRPASET
    • Amino acids
      1 to 141
    • Tags
      proprietary tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab164972 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    ELISA

    Western blot

  • Form
    Liquid
  • Additional notes
    Protein concentration is above or equal to 0.05 mg/ml.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • Cap specific guanine N2 methyltransferase
    • Cap-specific guanine-N2 methyltransferase
    • CLL associated antigen KW 2
    • CLL-associated antigen KW-2
    • DKFZp762A163
    • FLJ22995
    • HCA137
    • Hepatocellular carcinoma associated antigen 137
    • Hepatocellular carcinoma-associated antigen 137
    • NCOA6IP
    • Nuclear receptor coactivator 6 interacting protein
    • Nuclear receptor coactivator 6-interacting protein
    • PIMT
    • PIPMT
    • PRIP interacting protein PIPMT
    • PRIP interacting protein with methyltransferase domain
    • PRIP interacting protein with methyltransferase motif
    • PRIP-interacting protein with methyltransferase motif
    • SEREX defined
    • TGS 1
    • Tgs1
    • TGS1_HUMAN
    • Trimethylguanosine synthase
    • Trimethylguanosine synthase homolog
    • Trimethylguanosine synthase homolog (S. cerevisiae)
    see all
  • Function
    Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation.
  • Tissue specificity
    Ubiquitously expressed. High expression in heart, skeletal muscle, kidney, liver and placenta.
  • Sequence similarities
    Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family.
  • Cellular localization
    Cytoplasm. Nucleus > Cajal body. A 90 kDa isoform is found in the nucleus while a 55 kDa isoform is found in the cytoplasm and colocalizes with the tubulin network.
  • Information by UniProt

Images

  • ab164972 on a 12.5% SDS-PAGE stained with Coomassie Blue.

References

ab164972 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab164972.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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