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Alternative names
- 140 kDa nuclear and cell adhesion-related phosphoprotein
- Desmosome-associated protein
- Domain-rich serine protein
- DRS
- DRS protein
- DRSP
- Melanoma metastasis clone A protein
- MEMA
- Nuclear protein SDK3
- Pinin
- PININ_HUMAN
- PNN
- SR like protein
- SR-like protein
see all
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Function
Transcriptional activator binding to the E-box 1 core sequence of the E-cadherin promoter gene; the core-binding sequence is 5'CAGGTG-3'. Capable of reversing CTBP1-mediated transcription repression. Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Participates in the regulation of alternative pre-mRNA splicing. Associates to spliced mRNA within 60 nt upstream of the 5'-splice sites. Involved in the establishment and maintenance of epithelia cell-cell adhesion. Potential tumor suppressor for renal cell carcinoma.
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Tissue specificity
Expressed in placenta, lung, liver, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon, heart, epidermis, esophagus, brain and smooth and skeletal muscle. Expressed strongly in melanoma metastasis lesions and advanced primary tumors.
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Sequence similarities
Belongs to the pinin family.
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Post-translational
modifications
Phosphorylated upon DNA damage, probably by ATM or ATR.
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Cellular localization
Nucleus speckle. Cell junction > desmosome. Cell-cell contact area, predominantly desmosome of intercellular adherens junction. Not a nucleocytoplasmic shuttling protein.
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Information by UniProt