Overview

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • SpeciesHuman
    • SequenceMGSSHHHHHH SSGLVPRGSH MIRKVLLLKE DHEGLGISIT GGKEHGVPIL ISEIHPGQPA DRCGGLHVGD AILAVNGVNL RDTKHKEAVT ILSQQRGEIE FEVVYVAPEV DSDDENVEYE DESGHRYRLY LDELEGGGNP GASCKDTSGE IKVLQGFNKK AVTDTHENGD LGTASETPLD DGASKLDDLH TLYHKKSY
    • Amino acids278 to 454

Specifications

Our Abpromise guarantee covers the use of ab93743 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Purity> 90 % SDS-PAGE.
    ab93743 was purified using conventional chromatography techniques.
  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 10% Glycerol, 20mM Tris HCl, 1mM DTT, pH 8.0

General Info

  • Alternative names
    • CAL
    • CFTR associated ligand
    • CFTR-associated ligand
    • dJ94G16.2
    • dJ94G16.2 PIST
    • FIG
    • Fused in glioblastoma
    • Golgi associated PDZ and coiled coil motif containing
    • Golgi associated PDZ and coiled coil motif containing protein
    • Golgi-associated PDZ and coiled-coil motif-containing protein
    • GOPC
    • GOPC 1
    • GOPC_HUMAN
    • GOPC1
    • OTTHUMP00000040403
    • PDZ protein interacting specifically with TC 10
    • PDZ protein interacting specifically with TC10
    • PDZ/coiled coil domain binding partner for the rho family GTPase TC 10
    • PDZ/coiled coil domain binding partner for the rho family GTPase TC10
    • PIST
    • Protein interacting specifically with Tc 10
    • Protein interacting specifically with Tc10
    see all
  • FunctionPlays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ACCN3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Overexpression results in CFTR intracellular retention and degradation in the lysosomes.
  • Tissue specificityUbiquitously expressed.
  • Involvement in diseaseNote=A chromosomal aberration involving GOPC is found in a glioblastoma multiforme sample. An intra-chromosomal deletion del(6)(q21q21) is responsible for the formation of GOPC-ROS1 chimeric protein which has a constitutive receptor tyrosine kinase activity.
  • Sequence similaritiesContains 1 PDZ (DHR) domain.
  • DomainThe PDZ domain mediates interactions with FZD5, FZD8, ACCN3, GRID2, CLCN3 (By similarity). Mediates also interaction with CFTR and ADRB1.
    The coiled-coil region probably mediates association to membranes, targeting to the Golgi, and interactions with GOLGA3, and STX6. May also mediate interaction with RHOQ.
  • Cellular localizationCytoplasm. Golgi apparatus membrane. Golgi apparatus > trans-Golgi network membrane. Cell junction > synapse. Cell junction > synapse > postsynaptic cell membrane > postsynaptic density. Cell projection > dendrite. Enriched in synaptosomal and postsynaptic densities (PSD) fractions (By similarity). Expressed in cell bodies and dendrites of Purkinje cells (By similarity). Localized at the trans-Golgi network (TGN) of spermatids and the medulla of round spermatides.
  • Information by UniProt

Recombinant Human PIST protein images

  • 15% SDS-PAGE showing ab93743 (3ug)

References for Recombinant Human PIST protein (ab93743)

ab93743 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab93743.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"