Interferon induced double stranded RNA activated protein kinase
Interferon inducible elF2 alpha kinase
Interferon inducible RNA dependent protein kinase
Interferon-induced, double-stranded RNA-activated protein kinase
Interferon-inducible RNA-dependent protein kinase
P1/eIF-2A protein kinase
P1/eIF2A protein kinase
Protein kinase interferon inducible double stranded RNA dependent
Protein kinase RNA activated
Protein kinase RNA-activated
Protein phosphatase 1 regulatory subunit 83
Serine/threonine protein kinase TIK
Tyrosine protein kinase EIF2AK2
FunctionFollowing activation by double-stranded RNA in the presence of ATP, the kinase becomes autophosphorylated and can catalyze the phosphorylation of the translation initiation factor EIF2S1, which leads to an inhibition of the initiation of protein synthesis. Double-stranded RNA is generated during the course of a viral infection.
Sequence similaritiesBelongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily. Contains 2 DRBM (double-stranded RNA-binding) domains. Contains 1 protein kinase domain.
Post-translational modificationsAutophosphorylated on several Ser and Thr residues. Autophosphorylation of Thr-451 is dependent on Thr-446 and is stimulated by dsRNA binding and dimerization. Autophosphorylation apparently leads to the activation of the kinase.