Recombinant Human PPAR alpha protein (ab82045)

Overview

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Species
      Human
    • Amino acids
      170 to 468

Specifications

Our Abpromise guarantee covers the use of ab82045 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activity
    The protein has been tested in a SRC1 interaction assay and has been found to be ligand dependent.
  • Applications

    SDS-PAGE

  • Purity
    > 95 % SDS-PAGE.

  • Form
    Liquid
  • Additional notes
    The protein has been tested in a SRC1 interaction assay and has been found to be ligand dependent.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 20% Glycerol, 20mM Tris Cl, 100mM Potassium chloride, 1mM DTT, 0.2mM EDTA, pH 8.0

General Info

  • Alternative names
    • hPPAR
    • MGC2237
    • MGC2452
    • NR1C1
    • Nuclear receptor subfamily 1 group C member 1
    • OTTHUMP00000197740
    • OTTHUMP00000197741
    • Peroxisome proliferative activated receptor alpha
    • Peroxisome proliferator activated receptor alpha
    • Peroxisome proliferator-activated receptor alpha
    • PPAR
    • PPAR-alpha
    • ppara
    • PPARA_HUMAN
    • PPARalpha
    see all
  • Function
    Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety (By similarity). Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2.
  • Tissue specificity
    Skeletal muscle, liver, heart and kidney.
  • Sequence similarities
    Belongs to the nuclear hormone receptor family. NR1 subfamily.
    Contains 1 nuclear receptor DNA-binding domain.
  • Cellular localization
    Nucleus.
  • Information by UniProt

References for Recombinant Human PPAR alpha protein (ab82045)

ab82045 has not yet been referenced specifically in any publications.

Product Wall

Thank you for your email, and I sincerely apologize for the extended delay in resolving this problem.

I have been unable to obtain the lab protocol for the binding assay with ab82045, and due to this lack of information we may remove the prot...

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Thank you for your reply.

Yes, we will be sending a vial of the protein from a new lot.

We apprecipate your patience!

Thank you for your reply.

I apologize that we sent the incorrect information. I've asked the lab for the correct protocol, which I will forward to you as soon as possible. I am sorry for the delay and I will be back in touch shortly.
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Thank you for your call last week and for your patience while I have been in touch with the production lab regarding this protein.

Each lot is not tested in a binding assay, and the binding information was determined when the protein was init...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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