Recombinant Human PPAR gamma protein (ab83647)



  • Nature
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Species
    • Amino acids
      1 to 477


Our Abpromise guarantee covers the use of ab83647 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications


    Western blot

  • Form
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 20% Glycerol, 50mM Tris acetate, 1mM EDTA, pH 7.5

General Info

  • Alternative names
    • CIMT1
    • GLM1
    • NR1C3
    • Nuclear receptor subfamily 1 group C member 3
    • OTTHUMP00000185032
    • OTTHUMP00000185036
    • Peroxisome proliferator activated nuclear receptor gamma variant 1
    • Peroxisome Proliferator Activated Receptor gamma
    • Peroxisome proliferator activated receptor gamma 1
    • Peroxisome proliferator-activated receptor gamma
    • PPAR gamma
    • PPAR-gamma
    • PPARG
    • PPARG1
    • PPARG2
    • PPARgamma
    see all
  • Function
    Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis.
  • Tissue specificity
    Highest expression in adipose tissue. Lower in skeletal muscle, spleen, heart and liver. Also detectable in placenta, lung and ovary.
  • Involvement in disease
    Note=Defects in PPARG can lead to type 2 insulin-resistant diabetes and hyptertension. PPARG mutations may be associated with colon cancer.
    Defects in PPARG may be associated with susceptibility to obesity (OBESITY) [MIM:601665]. It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.
    Defects in PPARG are the cause of familial partial lipodystrophy type 3 (FPLD3) [MIM:604367]. Familial partial lipodystrophies (FPLD) are a heterogeneous group of genetic disorders characterized by marked loss of subcutaneous (sc) fat from the extremities. Affected individuals show an increased preponderance of insulin resistance, diabetes mellitus and dyslipidemia.
    Genetic variations in PPARG can be associated with susceptibility to glioma type 1 (GLM1) [MIM:137800]. Gliomas are central nervous system neoplasms derived from glial cells and comprise astrocytomas, glioblastoma multiforme, oligodendrogliomas, and ependymomas. Note=Polymorphic PPARG alleles have been found to be significantly over-represented among a cohort of American patients with sporadic glioblastoma multiforme suggesting a possible contribution to disease susceptibility.
  • Sequence similarities
    Belongs to the nuclear hormone receptor family. NR1 subfamily.
    Contains 1 nuclear receptor DNA-binding domain.
  • Cellular localization
  • Information by UniProt


ab83647 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

Thank you for your email. I am sorry this product did not perform as stated on the datasheet and for the inconvenience this has caused. As requested, I have issued a free of charge replacement with the order number xxx for ab53382. The estimated delive...

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Thank you for your patience. I have heard back from the lab: " We perform SDS-PAGE on the mother lot of material however we do not specifically check for degradation products. We retested this product in-house and did not obtain satisfactory results, ...

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Thank you for your reply and the additional information. I have not yet heard back from the lab regarding the QC testing of the protein. I would like to wait a little to get their input, and will send them another email today. Regarding the antibody: I...

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Thank you for contacting us. I am sorry to hear that the protein you purchased is not performing as expected. The problem could stem from the protein,the primary antibody or the secondary antibody, or any combination of these. In order to help you bett...

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