This product is an active protein and may elicit a biological response in vivo, handle with caution.
Peptidyl prolyl cis trans isomerase H
Peptidyl-prolyl cis-trans isomerase H
Peptidylprolyl isomerase H
Small nuclear ribonucleoprotein particle specific cyclophilin H
Small nuclear ribonucleoprotein particle-specific cyclophilin H
U snRNP associated cyclophilin SnuCyp 20
U-snRNP-associated cyclophilin SnuCyp-20
FunctionPPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Participates in pre-mRNA splicing. May play a role in the assembly of the U4/U5/U6 tri-snRNP complex. May act as a chaperone.
Sequence similaritiesBelongs to the cyclophilin-type PPIase family. PPIase H subfamily. Contains 1 PPIase cyclophilin-type domain.
Cellular localizationNucleus speckle. Cytoplasm. Colocalizes with spliceosomal snRNPs. A small proportion may also be cytoplasmic.