The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Protein concentration is above or equal to 0.05 mg/ml.
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Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.31% Glutathione, 0.79% Tris HCl
Ankyrin repeat domain containing protein 4
ankyrin repeat domain protein 4
Ankyrin repeat domain-containing protein 4
CAAX box protein TIMAP
Protein phosphatase 1 regulatory inhibitor subunit 16B
protein phosphatase 1, regulatory (inhibitor) subunit 16B
TGF beta inhibited membrane associated protein
TGF-beta-inhibited membrane-associated protein
Regulator of protein phosphatase 1 (PP1) that acts as a positive regulator of pulmonary endothelial cell (EC) barrier function. Involved in PKA-mediated moesin dephosphorylation which is important in EC barrier protection against thrombin stimulation. Promotes the interaction of PPP1CA with RPSA/LAMR1 and in turn facilitates the dephosphorylation of RPSA/LAMR1. Involved in the regulation of endothelial cell filopodia extension. May be a downstream target for TGF-beta1 signaling cascade in endothelial cells.
Highly expressed in vascular endothelium, CNS, lung, spleen, kidney and testis.
Contains 5 ANK repeats.
Phosphorylated by PKA and, after PKA priming, by GSK3B. Phosphorylation by GSK3B reduces its association with PP1C and enhances PP1C activity. Dephosphorylation by its associated PP1C results in enhanced association with PP1C, but reduced PP1C activity.
Cell membrane. Cell membrane. Nucleus. Co-localizes with RPSA/LAMR1 in the cell membrane.