Recombinant Human PPP1R3A protein (ab116962)

Overview

  • Product nameRecombinant Human PPP1R3A protein
  • Protein lengthProtein fragment

Description

  • NatureRecombinant
  • SourceWheat germ
  • Amino Acid Sequence
    • AccessionQ16821
    • SpeciesHuman
    • SequencePSEVPSQISKDNFLEVPNLSDSLCEDEEVTFQPGFSPQPSRRGSDSSEDI YLDTPSSGTRRVSFADSFGFNLVSVKEFDCWELPSASTTFDLGTDIFHT
    • Molecular weight37 kDa including tags
    • Amino acids3 to 101

Specifications

Our Abpromise guarantee covers the use of ab116962 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    ELISA

    SDS-PAGE

    Western blot

  • FormLiquid
  • Additional notesProtein concentration is above or equal to 0.05 mg/ml.
    Best used within three months from the date of receipt.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • Glycogen and sarcoplasmic reticulum binding subunit, skeletal muscle
    • Glycogen associated regulatory subunit of protein phosphatase 1
    • GM
    • PP1G
    • PPP1R3
    • PPP1R3A
    • PPR3A_HUMAN
    • Protein phosphatase 1 glycogen-associated regulatory subunit
    • Protein phosphatase 1 glycogen-targeting subunit, muscle
    • Protein phosphatase 1 regulatory subunit 3A
    • Protein phosphatase 1 regulatory subunit GM
    • protein phosphatase 1, regulatory (inhibitor) subunit 3A
    • Protein phosphatase 1, regulatory subunit 3
    • Protein phosphatase type-1 glycogen targeting subunit
    • RG1
    • Serine /threonine specific protein phosphatase
    • Type 1 protein phosphatase skeletal muscle glycogen targeting subunit
    see all
  • FunctionSeems to act as a glycogen-targeting subunit for PP1. PP1 is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Plays an important role in glycogen synthesis but is not essential for insulin activation of glycogen synthase.
  • Tissue specificitySkeletal muscle and heart.
  • Involvement in diseaseDiabetes mellitus, non-insulin-dependent
  • Sequence similaritiesContains 1 CBM21 (carbohydrate binding type-21) domain.
  • DomainThe CBM21 domain is known to be involved in the localization to glycogen and is characteristic of some regulatory subunit of phosphatase complexes.
  • Post-translational
    modifications
    Phosphorylation at Ser-46 by ISPK stimulates the dephosphorylation of glycogen synthase and phosphorylase kinase.
  • Cellular localizationMembrane.
  • Information by UniProt

Recombinant Human PPP1R3A protein images

  • 12.5% SDS-PAGE showing ab116962 at approximately 36.52kDa stained with Coomassie Blue.

References for Recombinant Human PPP1R3A protein (ab116962)

ab116962 has not yet been referenced specifically in any publications.

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