FunctionThe B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
Tissue specificityWidely expressed with the highest expression in heart and skeletal muscle.
Sequence similaritiesBelongs to the phosphatase 2A regulatory subunit B56 family.
Post-translational modificationsPhosphorylated on serine residues.
Cellular localizationCytoplasm. Nucleus. Chromosome > centromere. From mitotic prophase to metaphase, localizes at the inner centromere between a pair of sister kinetochores. Decreased expression at the onset of anaphase.