Recombinant Human PPP2R5C protein (ab114678)

Overview

Description

  • NatureRecombinant
  • SourceWheat germ
  • Amino Acid Sequence
    • AccessionQ13362
    • SpeciesHuman
    • SequenceMLTCNKAGSRMVVDAANSNGPFQPVVLLHIRDVPPADQEKLFIQKLRQCC VLFDFVSDPLSDLKWKEVKRAALSEMVEYITHNRNVITEPIYPEVVHMFA
    • Molecular weight37 kDa including tags
    • Amino acids1 to 100

Specifications

Our Abpromise guarantee covers the use of ab114678 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    SDS-PAGE

    ELISA

  • FormLiquid
  • Additional notesProtein concentration is above or equal to 0.05 mg/ml.
    Best used within three months from the date of receipt.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • 2A5G_HUMAN
    • B' alpha regulatory subunit
    • B56G
    • KIAA0044
    • MGC23064
    • PP2A B subunit B' gamma isoform
    • PP2A B subunit B56 gamma isoform
    • PP2A B subunit isoform B' gamma
    • PP2A B subunit isoform B''-gamma
    • PP2A B subunit isoform B56-gamma
    • PP2A B subunit isoform PR61-gamma
    • PP2A B subunit isoform R5-gamma
    • PP2A B subunit PR61 gamma isoform
    • PP2A B subunit R5 gamma isoform
    • Ppp2r5c
    • PR61G
    • Protein phosphatase 2 regulatory subunit B (B56) gamma isoform
    • Protein phosphatase 2 regulatory subunit B' gamma
    • Protein phosphatase 2, regulatory subunit B', gamma isoform
    • Renal carcinoma antigen NY REN 29
    • Renal carcinoma antigen NY-REN-29
    • Serine/threonine protein phosphatase 2A 56 kDa regulatory subunit gamma isoform
    • Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform
    see all
  • FunctionThe B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation.
  • Tissue specificityHighest levels in heart, skeletal muscle and brain. Lower levels in pancreas, kidney, lung and placenta. Very low levels in liver.
  • Sequence similaritiesBelongs to the phosphatase 2A regulatory subunit B56 family.
  • Post-translational
    modifications
    Isoform Gamma-3 is phosphorylated on serine residues. Isoform Gamma-1 phosphorylation by ERK2 is IER3-dependent and inhibits ERK dephosphorylation by PP2A-PPP2R5C.
  • Cellular localizationNucleus. Chromosome > centromere.
  • Information by UniProt

Recombinant Human PPP2R5C protein images

  • ab114678 analysed on a 12.5% SDS-PAGE gel stained with Coomassie Blue.

References for Recombinant Human PPP2R5C protein (ab114678)

ab114678 has not yet been referenced specifically in any publications.

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