HMT1 (hnRNP methyltransferase S. cerevisiae) like 2
HMT1 hnRNP methyltransferase
HMT1 hnRNP methyltransferase like 2
HMT1 hnRNP methyltransferase like 2 (S. cerevisiae)
Human mRNA for suppressor for yeast mutant
Human mRNA for suppressor for yeast mutant complete cds
Interferon receptor 1 bound protein 4
Interferon receptor 1 bound protein4
Interferon receptor 1-bound protein 4
Interferon receptor 1bound protein 4
Protein arginine methyltransferase 1
Protein arginine N methyltransferase 1
Protein arginine N methyltransferase1
Protein arginine N-methyltransferase 1
S. cerevisiae like 2
FunctionArginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in proteins such as ESR1, histone H2, H3 and H4, PIAS1, HNRNPA1, HNRNPD, NFATC2IP, SUPT5H, TAF15 and EWS. Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of histone H4 'Arg-4' (H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional activation. Together with dimethylated PIAS1, represses STAT1 transcriptional activity, in the late phase of interferon gamma (IFN-gamma) signaling. May be involved in the regulation of TAF15 transcriptional activity, act as an activator of estrogen receptor (ER)-mediated transactivation, play a key role in neurite outgrowth and act as a negative regulator of megakaryocytic differentiation, by modulating p38 MAPK pathway.
Tissue specificityWidely expressed.
Sequence similaritiesBelongs to the protein arginine N-methyltransferase family.