Recombinant Human PRMT2/HMT1 protein (ab131909)
Key features and details
- Expression system: Wheat germ
- Suitable for: WB, ELISA, SDS-PAGE
Description
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Product name
Recombinant Human PRMT2/HMT1 protein
See all PRMT2/HMT1 proteins and peptides -
Expression system
Wheat germ -
Accession
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Protein length
Full length protein -
Animal free
No -
Nature
Recombinant -
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Species
Human -
Sequence
MATSGDCPRSESQGEEPAECSEAGLLQEGVQPEEFVAIADYAATDETQLS FLRGEKILILRQTTADWWWGERAGCCGYIPANHVGKHVDEYDPEDTWQDE EYFGSYGTLKLHLEMLADQPRTTKYHSVILQNKESLTDKVILDVGCGTGI ISLFCAHYARPRAVYAVEASEMAQHTGQLVLQNGFADIITVYQQKVEDVV LPEKVDVLVSEWMGTCLLFEFMIESILYARDAWLKEDGVIWPTMAALHLV PCSADKDYRSKVLFWDNAYEFNLSALKSLAVKEFFSKPKYNHILKPEDCL SEPCTILQLDMRTVQISDLETLRGELRFDIRKAGTLHGFTAWFSVHFQSL QEGQPPQVLSTGPFHPTTHWKQTLFMMDDPVPVHTGDVVTGSVVLQRNPV WRRHMSVALSWAVTSRQDPTSQKVGEKVFPIWR -
Predicted molecular weight
75 kDa including tags -
Amino acids
1 to 433
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Specifications
Our Abpromise guarantee covers the use of ab131909 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Applications
Western blot
ELISA
SDS-PAGE
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Form
Liquid -
Additional notes
This product was previously labelled as PRMT2.
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Concentration information loading...
Preparation and Storage
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Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00
Constituents: 0.31% Glutathione, 0.79% Tris HCl
General Info
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Alternative names
- ANM2_HUMAN
- EC 2.1.1.
- histone arginine N methyltransferase PRMT2
see all -
Function
Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in proteins such as STAT3, FBL, histone H4. Acts as a coactivator (with NCOA2) of the androgen receptor (AR)-mediated transactivation. Acts as a coactivator (with estrogen) of estrogen receptor (ER)-mediated transactivation. Enhances PGR, PPARG, RARA-mediated transactivation. May inhibit NF-kappa-B transcription and promote apoptosis. Represses E2F1 transcriptional activity (in a RB1-dependent manner). May be involved in growth regulation. -
Tissue specificity
Widely expressed. Highly expressed in androgen target organs such as heart, prostate, skeletal muscle, ovary and spinal cord. -
Sequence similarities
Belongs to the protein arginine N-methyltransferase family.
Contains 1 SH3 domain. -
Cellular localization
Cytoplasm. Nucleus. Translocates from the cytoplasm to the nucleus, after hormone exposure. - Information by UniProt
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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Datasheet download
References (0)
ab131909 has not yet been referenced specifically in any publications.