Recombinant Human PRODH protein (ab114814)

Overview

Description

  • NatureRecombinant
  • SourceWheat germ
  • Amino Acid Sequence
    • AccessionO43272
    • SpeciesHuman
    • SequenceLVRGAYLAQERARAAEIGYEDPINPTYEATNAMYHRCLDYVLEELKHNAK AKVMVASHNEDTVRFALRRMEELGLHPADHRVYFGQLLGMCDQISFPLGQ
    • Molecular weight37 kDa including tags
    • Amino acids441 to 540

Specifications

Our Abpromise guarantee covers the use of ab114814 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    ELISA

    SDS-PAGE

    Western blot

  • FormLiquid
  • Additional notesProtein concentration is above or equal to 0.05 mg/ml.
    Best used within three months from the date of receipt.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • HSPOX2
    • mitochondrial
    • P53 induced gene 6 protein
    • p53-induced gene 6 protein
    • PIG6
    • POX
    • PROD_HUMAN
    • PRODH
    • PRODH 1
    • PRODH 2
    • PRODH1
    • PRODH2
    • Proline dehydrogenase
    • proline dehydrogenase (oxidase) 1
    • proline dehydrogenase (proline oxidase)
    • Proline dehydrogenase 1
    • Proline dehydrogenase 1, mitochondrial
    • Proline oxidase
    • Proline oxidase 1
    • Proline oxidase 2
    • Proline oxidase, mitochondrial
    • Proline oxidase, mitochondrial precursor
    • SCZD4
    • TP53I6
    • tumor protein p53 inducible protein 6
    see all
  • FunctionConverts proline to delta-1-pyrroline-5-carboxylate.
  • Tissue specificityExpressed in lung, skeletal muscle and brain, to a lesser extent in heart and kidney, and weakly in liver, placenta and pancreas.
  • PathwayAmino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 1/2.
  • Involvement in diseaseDefects in PRODH are the cause of hyperprolinemia type 1 (HP-1) [MIM:239500]. HP-1 is a disorder characterized by elevated serum proline levels. May be involved in the psychiatric and behavioral phenotypes associated with the 22q11 velocardiofacial and DiGeorge syndrome.
    Defects in PRODH are associated with susceptibility to schizophrenia type 4 (SCZD4) [MIM:600850]. A complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder.
  • Sequence similaritiesBelongs to the proline oxidase family.
  • Cellular localizationMitochondrion matrix.
  • Information by UniProt

Recombinant Human PRODH protein images

  • 12.5% SDS-PAGE Stained with Coomassie Blue

References for Recombinant Human PRODH protein (ab114814)

ab114814 has not yet been referenced specifically in any publications.

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The protein has not been tested for its activity so I am sorry we are unable to confirm. The protein should not be expected to be active because it is not a full length protein it is a fragment which was used as a ...

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