Recombinant Human ProDynorphin protein (ab114453)

Overview

Description

  • NatureRecombinant
  • SourceWheat germ
  • Amino Acid Sequence
    • AccessionP01213
    • SpeciesHuman
    • SequenceKRYGGFLRRIRPKLKWDNQKRYGGFLRRQFKVVTRSQEDPNAYSGELFDA
    • Molecular weight31 kDa including tags
    • Amino acids205 to 254

Specifications

Our Abpromise guarantee covers the use of ab114453 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    SDS-PAGE

    ELISA

  • FormLiquid
  • Additional notesProtein concentration is above or equal to 0.05 mg/ml.
    ab114453 is best used within three months from the date of receipt.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.79% Tris HCl, 0.3% Glutathione

General Info

  • Alternative names
    • ADCA
    • Alpha neoendorphin
    • Beta neoendorphin
    • Beta-neoendorphin-dynorphin
    • Big Dyn
    • Big dynorphin
    • Dyn
    • Dyn-A17
    • Dyn-B
    • Dynorphin A
    • Dynorphin A(1-13)
    • Dynorphin A(1-17)
    • Dynorphin A(1-8)
    • Dynorphin B
    • Dynorphin B(1-13)
    • Dynorphin B-29
    • Enkephalin B
    • Leu enkephalin
    • Leumorphin
    • Neoendorphin dynorphin enkephalin prepropeptide
    • PDYN
    • PDYN_HUMAN
    • PENKB
    • Preprodynorphin
    • Preproenkephalin B
    • Prodynorphin
    • Proenkephalin B
    • Rimorphin
    • SCA23
    see all
  • FunctionLeu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.
    Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opiod activity, it is 700 times more potent than Leu-enkephalin.
    Leumorphin has a typical opiod activity and may have anti-apoptotic effect.
  • Involvement in diseaseDefects in PDYN are the cause of spinocerebellar ataxia type 23 (SCA23) [MIM:610245]. Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA23 is an adult-onset autosomal dominant form characterized by slowly progressive gait and limb ataxia, with variable additional features, including peripheral neuropathy and dysarthria.
  • Sequence similaritiesBelongs to the opioid neuropeptide precursor family.
  • Post-translational
    modifications
    The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.
  • Cellular localizationSecreted.
  • Information by UniProt

Recombinant Human ProDynorphin protein images

  • ab114453 analysed on a 12.5% SDS-PAGE stained with Coomassie Blue.

References for Recombinant Human ProDynorphin protein (ab114453)

ab114453 has not yet been referenced specifically in any publications.

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