Recombinant human Prorenin protein (ab93266)

Overview

Description

  • NatureRecombinant
  • SourceHEK 293 cells
  • Amino Acid Sequence
    • SpeciesHuman

Specifications

Our Abpromise guarantee covers the use of ab93266 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activityFully activatable to renin by catalytic amounts of trypsin. ab93266 is > 95% active.
  • Applications

    SDS-PAGE

  • Purity> 95 % SDS-PAGE.
    ab93266 is purified by affinity chromatography.
  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 0.05M Sodium chloride, 0.05M Tris HCl, pH 8.0

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names
    • Angiotensin forming enzyme
    • Angiotensinogenase
    • FLJ10761
    • HNFJ2
    • REN
    • Ren1
    • RENAA
    • RENI_HUMAN
    • Renin
    • Renin precursor renal
    • Renin-1
    • Renin-2
    see all
  • FunctionRenin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.
  • Involvement in diseaseDefects in REN are a cause of renal tubular dysgenesis (RTD) [MIM:267430]. RTD is an autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype).
    Defects in REN are the cause of familial juvenile hyperuricemic nephropathy type 2 (HNFJ2) [MIM:613092]. It is a renal disease characterized by juvenile onset of hyperuricemia, slowly progressive renal failure and anemia.
  • Sequence similaritiesBelongs to the peptidase A1 family.
  • Cellular localizationSecreted. Membrane. Associated to membranes via binding to ATP6AP2.
  • Information by UniProt

Recombinant human Prorenin protein images

  • 10% SDS-PAGE
    Lane 1: ab93266 (3 ug) Non-reduced
    Lane 2: ab93266 (3 ug) Reduced
    Lane 3: Prestained Standard
  • 10% SDS-PAGE
    Lane 1: ab93266 (10 ug)
    Lane 2: Alternative Prorenin (10 ug)
    Lane 3: Prestained Standard

References for Recombinant human Prorenin protein (ab93266)

ab93266 has not yet been referenced specifically in any publications.

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