Recombinant Human Prostaglandin D Synthase (hematopoietic) protein (ab172856)
Key features and details
- Expression system: Escherichia coli
- Purity: > 95% SDS-PAGE
- Endotoxin level: = 1.000 Eu/µg
- Suitable for: SDS-PAGE, HPLC
Description
-
Product name
Recombinant Human Prostaglandin D Synthase (hematopoietic) protein
See all Prostaglandin D Synthase (hematopoietic) proteins and peptides -
Purity
> 95 % SDS-PAGE.
Purity greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE. ab172856 is 0.2 µM filtered. -
Endotoxin level
= 1.000 Eu/µg -
Expression system
Escherichia coli -
Accession
-
Protein length
Full length protein -
Animal free
No -
Nature
Recombinant -
-
Species
Human -
Sequence
GSHMPNYKLTYFNMRGRAEIIRYIFAYLDIQYEDHRIEQADWPEIKSTLP FGKIPILEVDGLTLHQSLAIARYLTKNTDLAGNTEMEQCHVDAIVDTLDD FMSCFPWAEKKQDVKEQMFNELLTYNAPHLMQDLDTYLGGREWLIGNSVT WADFYWEICSTTLLVFKPDLLDNHPRLVTLRKKVQAIPAVANWIK RRPQTKL -
Predicted molecular weight
23 kDa -
Amino acids
2 to 199
-
Specifications
Our Abpromise guarantee covers the use of ab172856 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
-
Applications
SDS-PAGE
HPLC
-
Form
Liquid -
Concentration information loading...
Preparation and Storage
-
Stability and Storage
Shipped on Dry Ice. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
pH: 7.00
Constituents: 1.17% Sodium chloride, 0.24% Tris
General Info
-
Alternative names
- Cerebrin 28
- Glutathione dependent PGD synthetase
- Glutathione S-transferase
see all -
Function
Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide. -
Tissue specificity
Expressed in a number of megakaryocytic cell lines but not in platelets. Highly expressed in adipose tissue, macrophages and placenta. Also expressed at lower levels in lung, heart, lymph nodes, appendix, bone marrow and fetal liver. -
Sequence similarities
Belongs to the GST superfamily. Sigma family.
Contains 1 GST C-terminal domain.
Contains 1 GST N-terminal domain. -
Developmental stage
Highest levels in immature megakaryocytic cells. Disappears after final differentiation to platelets. -
Cellular localization
Cytoplasm. - Information by UniProt
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
-
Datasheet download
References (0)
ab172856 has not yet been referenced specifically in any publications.