Recombinant Human Prostaglandin D Synthase (hematopoietic) protein (ab88041)

Overview

Description

  • NatureRecombinant
  • SourceSaccharomyces cerevisiae
  • Amino Acid Sequence
    • SpeciesHuman
    • SequenceMPNYKLTYFNMRGRAEIIRYIFAYLDIQYEDHRIEQADWPEIKSTLPFGK IPILE VDGLTLHQSLAIARYLTKNTDLAGNTEMEQCHVDAIVDTLDDF MSCFPWAEKKQD VKEQMFNELLTYNAPHLMQDLDTYLGGREWLIGNSV TWADFYWEICSTTLLVFKP DLLDNHPRLVTLRKKVQAIPAVANWIKRR PQTKL

Specifications

Our Abpromise guarantee covers the use of ab88041 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 30% Glycerol, 0.5% Triton-X-100, 50mM HEPES, 30mM Glutathione, 100mM Sodium chloride, 1mM DTT, pH 7.5

General Info

  • Alternative names
    • Cerebrin 28
    • Glutathione dependent PGD synthetase
    • Glutathione S-transferase
    • Glutathione-dependent PGD synthase
    • Glutathione-requiring prostaglandin D synthase
    • GST class-sigma
    • H PGDS
    • H-PGDS
    • Haematopoietic prostaglandin D synthase
    • Haematopoietic prostaglandin D2 synthase
    • Hematopoietic prostaglandin D synthase
    • Hpgds
    • HPGDS_HUMAN
    • Prostaglandin D synthase
    • Prostaglandin D2 synthase hematopoietic
    • Prostaglandin H2 D isomerase
    • Prostaglandin-H2 D-isomerase
    • PTGDS2
    see all
  • FunctionBifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide.
  • Tissue specificityExpressed in a number of megakaryocytic cell lines but not in platelets. Highly expressed in adipose tissue, macrophages and placenta. Also expressed at lower levels in lung, heart, lymph nodes, appendix, bone marrow and fetal liver.
  • Sequence similaritiesBelongs to the GST superfamily. Sigma family.
    Contains 1 GST C-terminal domain.
    Contains 1 GST N-terminal domain.
  • Developmental stageHighest levels in immature megakaryocytic cells. Disappears after final differentiation to platelets.
  • Cellular localizationCytoplasm.
  • Information by UniProt

References for Recombinant Human Prostaglandin D Synthase (hematopoietic) protein (ab88041)

ab88041 has not yet been referenced specifically in any publications.

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