Proteasome (prosome macropain) subunit alpha type 3
Proteasome alpha 3 subunit
Proteasome component C8
Proteasome subunit alpha type 3
Proteasome subunit alpha type-3
Proteasome subunit C8
FunctionThe proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Binds to the C-terminus of CDKN1A and thereby mediates its degradation. Negatively regulates the membrane trafficking of the cell-surface thromboxane A2 receptor (TBXA2R) isoform 2.
Sequence similaritiesBelongs to the peptidase T1A family.