The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
% SDS-PAGE. ab123208 is purified by using conventional chromatography. Purity is > 80% by SDS-PAGE.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
pH: 8.00 Constituents: 0.02% DTT, 0.32% Tris HCl, 20% Glycerol
Macropain chain Z
Multicatalytic endopeptidase complex chain Z
Proteasome (prosome macropain) subunit beta type 7
Proteasome beta 7 subunit
Proteasome catalytic subunit 2
Proteasome subunit alpha
Proteasome subunit beta 7
Proteasome subunit beta type-7
Proteasome subunit Z
FunctionThe proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This unit is responsible of the trypsin-like activity.
Tissue specificityExpressed at a low level in colonic mucosa. Up-regulated in colorectal cancer tissues.
Sequence similaritiesBelongs to the peptidase T1B family.