Recombinant Human Protein Kinase A regulatory subunit I alpha (ab125532)

Overview

Description

  • NatureRecombinant
  • SourceBaculovirus infected Sf9 cells
  • Amino Acid Sequence
    • AccessionP10644
    • SpeciesHuman
    • Molecular weight51 kDa including tags
    • Amino acids1 to 381

Specifications

Our Abpromise guarantee covers the use of ab125532 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    SDS-PAGE

  • Purity> 85 % Densitometry.
    Purity determined to be >85% by densitometry.
  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 7.00
    Preservative: 1.02% Imidazole
    Constituents: 0.002% PMSF, 0.82% Sodium phosphate, 0.0038% DTT, 25% Glycerol, 1.75% Sodium chloride

General Info

  • Alternative names
    • ACRDYS1
    • ADOHR
    • cAMP dependent protein kinase regulatory subunit alpha 1
    • cAMP dependent protein kinase regulatory subunit RIalpha
    • cAMP dependent protein kinase type I alpha regulatory chain
    • cAMP dependent protein kinase type I alpha regulatory subunit
    • cAMP-dependent protein kinase type I-alpha regulatory subunit
    • CAR
    • Carney complex type 1
    • CNC
    • CNC 1
    • CNC1
    • DKFZp779L0468
    • KAP0_HUMAN
    • MGC17251
    • PKA RIA
    • PKR 1
    • PKR1
    • PPNAD 1
    • PPNAD1
    • PRKAR 1
    • PRKAR1
    • PRKAR1A
    • PRKAR1A/RARA FUSION GENE
    • Protein kinase A type 1a regulatory subunit
    • Protein kinase cAMP dependent regulatory type I alpha
    • PTC2 CHIMERIC ONCOGENE, INCLUDED
    • Tissue specific extinguisher 1
    • Tissue-specific extinguisher 1
    • TSE 1
    • TSE1
    see all
  • Tissue specificityFour types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible.
  • Involvement in diseaseDefects in PRKAR1A are the cause of Carney complex type 1 (CNC1) [MIM:160980]. CNC is a multiple neoplasia syndrome characterized by spotty skin pigmentation, cardiac and other myxomas, endocrine tumors, and psammomatous melanotic schwannomas.
    Defects in PRKAR1A are the cause of intracardiac myxoma (INTMYX) [MIM:255960]. Inheritance is autosomal recessive.
    Defects in PRKAR1A are the cause of primary pigmented nodular adrenocortical disease type 1 (PPNAD1) [MIM:610489]. Primary pigmented nodular adrenocortical disease is a rare bilateral adrenal defect causing ACTH-independent Cushing syndrome. Macroscopic appearance of the adrenals is characteristic with small pigmented micronodules observed in the cortex. PPNAD1 is most often diagnosed in patients with Carney complex, but it can also be observed in patients without other manifestations or familial history.
  • Sequence similaritiesBelongs to the cAMP-dependent kinase regulatory chain family.
    Contains 2 cyclic nucleotide-binding domains.
  • Post-translational
    modifications
    The pseudophosphorylation site binds to the substrate-binding region of the catalytic chain, resulting in the inhibition of its activity.
  • Information by UniProt

Recombinant Human Protein Kinase A regulatory subunit I alpha images

  • SDS-PAGE analysis of ab125532.

References for Recombinant Human Protein Kinase A regulatory subunit I alpha (ab125532)

ab125532 has not yet been referenced specifically in any publications.

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