Recombinant Human Protein Phosphatase 1 beta (ab126018)

Overview

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • AccessionP62140
    • SpeciesHuman
    • Amino acids30 to 319

Specifications

Our Abpromise guarantee covers the use of ab126018 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • FormLyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C.

    Constituents: 0.32% Tris HCl, 0.58% Sodium chloride

  • ReconstitutionReconstitute with water to desired concentration.

General Info

  • Alternative names
    • MGC3672
    • PP 1B
    • PP-1B
    • PP1B
    • PP1B_HUMAN
    • PP1beta
    • PPP1CB
    • PPP1CD
    • Protein phosphatase 1 beta
    • Protein phosphatase 1 catalytic subunit beta isoform
    • Protein phosphatase 1 delta
    • Protein phosphatase 1, catalytic subunit, beta isozyme
    • Protein phosphatase 1, catalytic subunit, delta isoform
    • Serine threonine protein phosphatase PP1 beta catalytic subunit
    • Serine/threonine-protein phosphatase PP1-beta catalytic subunit
    see all
  • FunctionProtein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208).
  • Sequence similaritiesBelongs to the PPP phosphatase family. PP-1 subfamily.
  • Cellular localizationCytoplasm. Nucleus. Nucleus, nucleoplasm. Nucleus, nucleolus. Highly mobile in cells and can be relocalized through interaction with targeting subunits. In the presence of PPP1R8 relocalizes from the nucleus to nuclear speckles.
  • Information by UniProt

References for Recombinant Human Protein Phosphatase 1 beta (ab126018)

ab126018 has not yet been referenced specifically in any publications.

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