Overview

  • Product name
    Recombinant Human PROX1 protein
  • Protein length
    Protein fragment

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Sequence
      MAEGLSLSLIKSECGDLQDMSEISPYSGSAMQEGLSPNHLKKAKLMFFYT RYPSSNMLKTYFSDVKFNRCITSQLIKWFSNFREFYYIQMEKYARQAIND GVTSTEELSITRDCELYRALNMHYNKANDFEVPERFLEVAQITLREFFNA IIAGKDVDPSWKKAIYKVICKLDSEVPEIFKSPNCLQELLHE
    • Molecular weight
      22 kDa
    • Amino acids
      547 to 737

Specifications

Our Abpromise guarantee covers the use of ab54337 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Purity
    > 95 % SDS-PAGE.
    >95% by SDS-PHAGE & silver stain.
  • Form
    Lyophilised
  • Additional notes

    This product can be used as a positive control e.g. in Western analysis.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Constituent: PBS

  • Reconstitution
    Reconstitute in water to a concentration not lower than 50 µg/ml.

General Info

  • Alternative names
    • Homeobox prospero like protein
    • Homeobox prospero like protein PROX1
    • Homeobox prospero-like protein PROX1
    • Prospero homeobox 1
    • Prospero homeobox protein 1
    • Prospero related homeobox 1
    • prospero-related homeobox gene 1
    • PROX 1
    • PROX-1
    • PROX1
    • PROX1_HUMAN
    • zgc:111888
    see all
  • Function
    Transcription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. Plays a critical role in embryonic development and functions as a key regulatory protein in neurogenesis and the development of the heart, eye lens, liver, pancreas and the lymphatic system. Involved in the regulation of the circadian rhythm. Represses: transcription of the retinoid-related orphan receptor RORG, transcriptional activator activity of RORA and RORG and the expression of RORA/G-target genes including core clock components: ARNTL/BMAL1, NPAS2 and CRY1 and metabolic genes: AVPR1A and ELOVL3.
  • Tissue specificity
    Most actively expressed in the developing lens. Detected also in embryonic brain, lung, liver and kidney. In adult, it is more abundant in heart and liver than in brain, skeletal muscle, kidney and pancreas.
  • Sequence similarities
    Belongs to the Prospero homeobox family.
    Contains 1 Prospero-type homeobox DNA-binding domain.
  • Domain
    The prospero-type homeobox DNA-binding domain is essential for repression of RORG transcriptional activator activity.
  • Cellular localization
    Nucleus. RORG promotes its nuclear localization.
  • Information by UniProt

Recombinant Human PROX1 protein images

  • SDS-PAGE analysis of recombinant human PROX1 protein fragment (ab54337). The sample was loaded in 15% SDS-polyacrylamide gel under reducing conditions and stained with Coomassie blue.

References for Recombinant Human PROX1 protein (ab54337)

ab54337 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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