Overview

  • Product nameRecombinant Human PROX1 protein
  • Protein lengthProtein fragment

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • AccessionQ92786
    • SpeciesHuman
    • SequenceMAEGLSLSLIKSECGDLQDMSEISPYSGSAMQEGLSPNHLKKAKLMFFYT RYPSSNMLKTYFSDVKFNRCITSQLIKWFSNFREFYYIQMEKYARQAIND GVTSTEELSITRDCELYRALNMHYNKANDFEVPERFLEVAQITLREFFNA IIAGKDVDPSWKKAIYKVICKLDSEVPEIFKSPNCLQELLHE
    • Molecular weight22 kDa
    • Amino acids547 to 737

Specifications

Our Abpromise guarantee covers the use of ab54337 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Purity> 95 % SDS-PAGE.
    >95% by SDS-PHAGE & silver stain.
  • FormLyophilised
  • Additional notes

    This product can be used as a positive control e.g. in Western analysis.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Constituent: PBS

  • ReconstitutionReconstitute in water to a concentration not lower than 50 µg/ml.

General Info

  • Alternative names
    • Homeobox prospero like protein
    • Homeobox prospero like protein PROX1
    • Homeobox prospero-like protein PROX1
    • Prospero homeobox 1
    • Prospero homeobox protein 1
    • Prospero related homeobox 1
    • prospero-related homeobox gene 1
    • PROX 1
    • PROX-1
    • PROX1
    • PROX1_HUMAN
    • zgc:111888
    see all
  • FunctionTranscription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. Plays a critical role in embryonic development and functions as a key regulatory protein in neurogenesis and the development of the heart, eye lens, liver, pancreas and the lymphatic system. Involved in the regulation of the circadian rhythm. Represses: transcription of the retinoid-related orphan receptor RORG, transcriptional activator activity of RORA and RORG and the expression of RORA/G-target genes including core clock components: ARNTL/BMAL1, NPAS2 and CRY1 and metabolic genes: AVPR1A and ELOVL3.
  • Tissue specificityMost actively expressed in the developing lens. Detected also in embryonic brain, lung, liver and kidney. In adult, it is more abundant in heart and liver than in brain, skeletal muscle, kidney and pancreas.
  • Sequence similaritiesBelongs to the Prospero homeobox family.
    Contains 1 Prospero-type homeobox DNA-binding domain.
  • DomainThe prospero-type homeobox DNA-binding domain is essential for repression of RORG transcriptional activator activity.
  • Cellular localizationNucleus. RORG promotes its nuclear localization.
  • Information by UniProt

Recombinant Human PROX1 protein images

  • SDS-PAGE analysis of recombinant human PROX1 protein fragment (ab54337). The sample was loaded in 15% SDS-polyacrylamide gel under reducing conditions and stained with Coomassie blue.

References for Recombinant Human PROX1 protein (ab54337)

ab54337 has not yet been referenced specifically in any publications.

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